The title compound, C(8)H(10)ClNO(5), was obtained via a tandem Michael addition-elimination reaction of 3,4-dichloro-5-meth-oxy-furan-2(5H)-one and glycine methyl ester in the presence of triethyl-amine. The mol-ecular structure contains an approximately planar [maximum atomic deviation = 0.010 (2) Å] five-membered furan-one ring. The crystal packing is stabilized by inter-molecular N-H⋯O and ...

The title compound, C(13)H(11)NO(3)S, was synthesized from methyl anthranilate, triethyl-amine and 2-thio-phenoyl chloride in benzene. The mol-ecular conformation is stabilized by an intra-molecular N-H⋯O hydrogen bond. The dihedral angle between the rings is 2.74 (12)°. In the crystal, C-H⋯O inter-actions link neighbouring mol-ecules into a three-dimensional network.

With the emergence of novel and more effective drug therapies, increased importance is being placed upon the drug delivery technology. Topical formulations are attractive alternatives to oral formulations and offer several advantages, such as avoiding first-pass hepatic metabolism and gastric degradation. The major obstacle to drug delivery across the skin (transdermal) is the barrier nature of...

Emergence of multidrug-resistant and extreme-drug-resistant strains of Mycobacterium tuberculosis (MTb) can cause serious socioeconomic burdens. Arabinogalactan present on the cellular envelope of MTb is unique and is required for its survival; access to arabinogalactan is essential for understanding the biosynthetic machinery that assembles it. Isolation from Nature is a herculean task and, as...

The influence of temperature, reaction time, and type the catalyst on yield 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal methylethylketone was investigated. 3-Amino-2-methylpropenal synthesized 3-ethoxy-2-methylacrolein previously methylmalondialdehyde tetraethyl acetal, obtained triethyl orthoformate propenyl ether. optimal conditions for investigated synthesis were temper...

silica sulfuric acid as an efficient and reusable heterogeneous catalyst has been used for the preparation of amidines 2 from formimidate 1 by reaction with aromatic amines at room temperature in good to excellent yields. imidate was prepared by treatment of equimolar quantities of triethyl orthoformate and diaminomaleonitrile in refluxing dioxane. all the compounds were characterized fully by ...

GaAs-based multiple quantum well (MQW) heterostructures comprised of metastable alloys such as GaAs1 ySby-GaAs1 zNz have potential for realizing high-performance and low temperature-sensitivity lasers in the 1.55 mm wavelength region. However, straininduced ‘lattice-latching’ and Sb-surface segregation effects limit the Sb-mole fractions in the pseudomorphically strained GaAs1 ySby layers to yp...

Phosphotriesterase (PTE) from Pseudomonas diminuta catalyzes the detoxification of organophosphates such as the widely utilized insecticide paraoxon and the chemical warfare agent sarin. The three-dimensional structure of the enzyme is known from high resolution x-ray crystallographic analyses. Each subunit of the homodimer folds into a so-called TIM barrel, with eight strands of parallel beta-...