I read the review article by Wijkstra et al (2006) with much interest as I found the results in the abstract quite striking. However, I wish to raise a few points about the methodology and description of results. First, the authors have concluded from two studies by Bruijn et al (1996) and van den Broek et al (2004) that tricyclic antidepressants (TCAs) are more efficacious than non-TCAs in tre...

BACKGROUND Multiple treatments for painful diabetic peripheral neuropathy are available. PURPOSE To evaluate the comparative effectiveness of oral and topical analgesics for diabetic neuropathy. DATA SOURCES Multiple electronic databases between January 2007 and April 2014, without language restriction. STUDY SELECTION Parallel or crossover randomized, controlled trials that evaluated pha...

Tricyclic antidepressants have a long history in the treatment of headache. In 1964 Lance and Curran reported a better response to amitriptyline (30-75 mg/day) in chronic tension headache (n=280) compared with 11 other commonly used drugs (such as benzodiazepines, vasodilators, and sedatives). They also reported a placebo controlled crossover trial of 27 patients that showed clinically signific...

Affective disorders are a group of psychiatric diseases that can affect an individual at any given age. Also called mood disorders, they can be distinguished into two different types: major depressive disorder, also called major depression, and bipolar disorder, which is known as manic depression. People affected by major depression most often have a low mood, and are consistently in a state of...

We describe automated column-switching high-performance liquid chromatography for determining nine tricyclic and tetracyclic antidepressants (TCAs) and their metabolites in human serum. TSKgel ODS-80TM and TSKprecolumn PW (Tosoh Co., Tokyo) are used in the analytical column and the precolumn, respectively. A 200-microL serum sample is directly injected onto the precolumn. After washing the seru...

Case note data were obtained for 186 elderly primary care attenders who also completed the 15 item Geriatric Depression Scale (GDS15). The presence or absence in the case notes of a current or past diagnosis of depression, of current treatment of depression, and of a number of clinical features of depression were noted. Case notes were also rated for the presence or absence of contraindications...

I read the review article by Wijkstra et al (2006) with much interest as I found the results in the abstract quite striking. However, I wish to raise a few points about the methodology and description of results. First, the authors have concluded from two studies by Bruijn et al (1996) and van den Broek et al (2004) that tricyclic antidepressants (TCAs) are more efficacious than non-TCAs in tre...

I read the review article by Wijkstra et al (2006) with much interest as I found the results in the abstract quite striking. However, I wish to raise a few points about the methodology and description of results. First, the authors have concluded from two studies by Bruijn et al (1996) and van den Broek et al (2004) that tricyclic antidepressants (TCAs) are more efficacious than non-TCAs in tre...