We evaluated 147 patients with adequate color Doppler and angiographic studies for mitral regurgitation. Sixty-five patients had no mitral regurgitation by both color Doppler and angiography and 82 patients had mitral regurgitation by both techniques. Thus the sensitivity and specificity of color Doppler for the detection of mitral regurgitation was 100%. Three two-dimensional echocardiographic...

T he prevalence of valve regurgitation in healthy people has been previously examined by echocardiography. Pulmonary regurgitation or tricuspid regurgitation (TR) was common, mitral regurgitation (MR) was less common, and aortic regurgitation was generally undetectable. In addition, the prevalence of regurgitant signals varies with age or sex. Assuming that a low prevalence of regurgitant signa...

Pulmonary hypertension is associated with reduced nitric oxide bioavailability and early mortality in sickle cell disease (SCD). We previously demonstrated that placenta growth factor (PlGF), an angiogenic factor produced by erythroid cells, induces hypoxia-independent expression of the pulmonary vasoconstrictor endothelin-1 in pulmonary endothelial cells. Using a lentivirus vector, we simulate...

Angiographic results in patients with mitral regurgitation suggest that up to 50% of the regurgitant volume occurs during the preejection period. This contrasts markedly with the electromagnetic measurements of mitral regurgitant flow in anesthetized dogs, which suggest that only 5% of mitral regurgitant flow occurs during the preejection period. Therefore, we used two-dimensional and Doppler e...

An axisymmetric jet issued from a sharp edged circular convergent nozzle has been studied experimentally in the near field at Reynolds number 5.3x104  to search the saddle shape behavior of mean velocity and the role of mean static pressure in the jet flow. Due to the vena contracta effect the centerline mean velocity of the jet increases about 4.2% of its exit value and corresponding decrease ...

A 69 year old female with a history of gastric bypass surgery with a recent revision (12 weeks prior to presentation) was admitted from a skilled nursing facility with subacute progressive dyspnea, cough and pleuritic chest pain. On initial assessment her blood pressure was 150/80 mmHg, pulse of 130 beats per minute, with a respiratory rate of 30 per minute and oxygen saturation of 85%. She had...

Elevated Tricuspid Regurgitant Velocity (TRV) has been related to higher mortality in adults and to hemolysis, lower oxygen saturation during 6-minute walk test and acute chest syndrome (ACS) in children with sickle cell disease (SCD). Hydroxyurea (HU) has reduced TRV value in children and adults. We describe a three year old HbSS child with recurrent ACS, hypoperfusion of the left lung, mild h...

To study the mechanism of altered mitral function in the presence of an isolated cleft mitral valve (ICMV) with regard to the relative roles of the cleft and of the accessory chordae, seven patients with ICMV were studied with color Doppler echocardiography. Mitral insufficiency ranging from mild to severe was demonstrated in six cases. The regurgitant jet originated in each case from the site ...