The Food and Drug Administration (FDA) recently released a final rule to ban triclosan and 18 other antimicrobial chemicals from soaps. We applaud this rule specifically because of the associated risks that triclosan poses to the spread of antibiotic resistance throughout the environment. This persistent chemical constantly stresses bacteria to adapt, and behavior that promotes antibiotic resis...

OBJECTIVE In vitro testing of antimicrobial agents is an important tool in the testing hierarchy, and may provide interesting insights into their potential clinical efficacy. Agents with demonstrable in vitro antimicrobial activity may be effective against the same microorganisms in vivo, whereas agents without demonstrable in vitro antimicrobial activity are unlikely to exhibit in vivo antimic...

BACKGROUND Triclosan is a widely used antimicrobial compound and emerging environmental contaminant. Although the role of the gut microbiome in health and disease is increasingly well established, the interaction between environmental contaminants and host microbiome is largely unexplored, with unknown consequences for host health. This study examined the effects of low, environmentally relevan...

We read with interest Thimour-Bergström et al.’s recent article [1] on the randomized trial evaluating the effect of triclosan-coated sutures on the rate of surgical site infection (SSI) after open vein bypass grafting procedures. The authors’ report that leg-wound closure with triclosan-coated sutures reduces the SSI rate in coronary artery bypass surgery (CABG) patients after open vein harves...

BACKGROUND Surgical site infections (SSI) are the third most common hospital-acquired infections and account for 14% to 16% of all such infections. In elective colorectal operations, the international SSI rate ranges from 4.7%-25%. In a previous retrospective study in this department, the SSI rate was unacceptably high (25%), and the promising different international evaluations of triclosan-co...

The antimicrobial triclosan was analyzed in unfiltered samples from influent, effluent, and receiving stream and before and after a pilot-scale constructed wetland at a North Texas municipal wastewater treatment plant. Triclosan concentrations were reduced by 97 to 99% by the activated sludge treatment plant. Effluent concentrations were further reduced by passage through the constructed wetlan...

Maintenance of recombinant plasmid vectors in host bacteria relies on the presence of selection antibiotics in the growth media to suppress plasmid -free segregants. However, presence of antibiotic resistance genes and antibiotics themselves is not acceptable in several applications of biotechnology. Previously, we have shown that FabV-Triclosan selection system can be used to select high and m...

Recent studies have demonstrated that submicromolar concentrations of the biocide triclosan arrest the growth of the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii and inhibit the activity of the apicomplexan enoyl acyl carrier protein reductase (ENR). The crystal structures of T. gondii and P. falciparum ENR in complex with NAD(+) and triclosan and of T. gondii ENR in an ap...

The ability of purified multi-walled carbon nanotubes (MWCNTs) to adsorb diclofenac and triclosan in aqueous solutions was examined by equilibrium, kinetic, and thermodynamic parameters. The results of SEM image, BET specific surface area, XRD, TGA, and FTIR spectra indicated that the characteristics of MWCNTs were improved after purification with nitric acid. Batch experiments illustrated that...

BACKGROUND Sternal wound infections are a major complication after cardiac surgery in terms of morbidity and cost increase. To decrease the incidence of infection, we evaluated triclosan-coated sutures for the closure of the sternal incision, as it is known that most of the surgical site infections are related to the incision site. METHODS From May to December 2005, a total of 479 patients un...