MOTIVATION Liquid chromatography tandem mass spectrometry (LC-MS/MS) is the predominant method to comprehensively characterize complex protein mixtures such as samples from prefractionated or complete proteomes. In order to maximize proteome coverage for the studied sample, i.e. identify as many traceable proteins as possible, LC-MS/MS experiments are typically repeated extensively and the resu...

The availability of high-throughput genomic databases that establish protein dispensability, expression and interaction networks enables rigorous tests of competing models of protein evolution. Recent research utilizing these new data sets shows that protein evolution is more complex than was previously thought. Several variables, including protein dispensability, expression, functional density...

Proteomes are intricate. Typically, thousands of proteins interact through physical association and post-translational modifications (PTMs) to give rise to the emergent functions of cells. Understanding these functions requires one to study proteomes as "systems" rather than collections of individual protein molecules. The abstraction of the interacting proteome to "protein networks" has recent...

mitochondria play key roles in many cell functions including energy production, fatty acid metabolism, pyrimidine biosynthesis, calcium homeostasis, and aging. they also regulate crucial signaling cascades such as apoptosis and oxidative stress. the proteome is often used to investigate the functional correlations on protein levels. based upon the human, genome there is estimated 2000 to 2500 a...

Background—Fascioliasis is a parasitic infection, primarily of the liver but after several weeks the biliary tract may also be aVected, related to the trematode Fasciola hepatica. The trematode is distributed worldwide in herbivores but is unusual in humans. Several outbreaks have been attributed to consumption of contaminated watercress and water. The optimal treatment of fascioliasis, particu...

The aim of this study was to evaluate the therapeutic efficacy of six different commercial anthelmintics preparations against naturally occurring gastrointestinal parasitic infestation in sheep was conducted from July to August, 2006 in the Veterinary clinics in collaboration with Department of Medicine, Department of Parasitology, Department of Pharmacology and Department of Physiology of of B...