Synthesis of 2,3- and 3,4-cyclopentenopyridines, 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines from 1,2,4-triazine derivatives is reported. Introduction of an alpha-functionalized methyl substituent (e.g. arylsulphonyl, sulphonamide, sulphonic acid ester) into position 3- or 6- of triazines by vicarious nucleophilic substitution of hydrogen and subsequent alkylation with alky...

The kinetics o f inhibition o f photosystem II electron transfer by different diuron-like herbi­ cides (ureas, triazines, triazinones. biscarbam ates, uraciles) were studied, mainly by chloro­ phyll fluorescence measurem ents. Uracil derivatives and cyanazine, a particu lar triazine, were the slowest acting com pounds. The half-times o f action were strongly tem perature-dependent and were o f ...

C-Ribosyl 1,2,4-triazolo[1,2,4]triazines which are able to undergo covalent hydration are of interest as potential inhibitors of AMP deaminase. In a search for compounds with improved bioavailability we have synthesized compounds in which the sugar has been replaced by carboxyarylalkyl based ribose phosphate mimics. The target carboxyarylalkyl imidazotriazines 11 and 12 were synthesized using a...

Two series of 2–(4–cyanophenyl amino)–4–quinoline (quinazoline)–4–yloxy–6–piperazinyl (piperidinyl)–1,3,5–triazines were synthesized so as to investigate their antimicrobial and antitubercular action. Newer analogues were characterized by IR, H NMR spectroscopy and elemental analyses. Pharmacological screening against eight bacteria (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, ...

In this paper the Multi-linear regression analysis has been applied for QSAR study. The relationship has been worked out between the Log 1/C values of a series of compounds and certain quantum chemical and energy descriptors. The QSAR studies of Triazines inhibiting dihydrofolate reductase based on quantum chemical and energy descriptors shows that among all the 28 QSAR models PA51 to PA 78, th...

A new group of compounds analogous to the purines was recently described (1) in which carbon atom 2 of the purine ring was replaced by nitrogen. One of these imidazo-1 ,2,3-triazines (I), conveniently called 2-azaadenine, was shown to be an antagonist of hypoxanthine and of adenine in its toxic action against bacteria and mice. The corresponding hydroxy compound, 2-azahypoxanthine, was relative...

The title compound, C(13)H(9)BrF(3)N(5)O, crystallizes with two independent mol-ecules in the asymmetric unit. The pyrimidine rings of the mol-ecules are planar [maximum deviations 0.053 (3) and 0.012 (3) Å], while the triazine rings adopt flattened half-boat conformations with the p-bromo-phenyl rings in the flagpole positions. The crystal packing is stabilized by a three-dimensional network o...