introduction the morphologic features of human sperms are key indicators for monitoring fertility problems in men. therefore, automated analyzing methods via microscopic videos have become the most favorite policy in infertility treatment during the last decades. materials and methods in the proposed method, firstly a hypothesis testing framework was defined to distinguish sperms from backgroun...

Metastatic renal-cell cancer (mRCC) is considered incurable, and systemic therapy is the foundation of patient management. Historically, hormonal therapy was used for palliation of symptoms but had little anti-cancer effect [1]; cytotoxic chemotherapy is beneficial for only a small proportion of patients [2–7]. Immunotherapy, generally interferon-alpha (IFNa), was standard treatment until 2005,...

Achilles tendinopathy affects athletes, recreational exercisers and even inactive people. The pathology is not inflammatory; it is a failed healing response. The source of pain in tendinopathy could be related to the neurovascular ingrowth seen in the tendon's response to injury. The treatment of Achilles tendinopathy is primarily conservative with an array of effective treatment options now av...

We report a computational 'alloy by design' approach which can significantly accelerate the design process and substantially reduce the development costs. This approach allows simultaneously optimization of alloy composition and heat treatment parameters based on the integration of thermodynamic, thermo-kinetics and a genetic algorithm optimization route. Novel steel compositions and associated...

PURPOSE To optimize dose distribution for prostate cancer in low-dose-rate interstitial brachytherapy, we have developed a new algorithm named the Attraction-Repulsion Model. The purpose was to find the optimal source configuration. METHODS AND MATERIALS The Attraction-Repulsion Model is used to optimize the dose distribution by finding the best seed configuration. We arranged grids at interv...

The pencil-beam algorithm is valid only when elementary Gaussian beams are small enough compared to the lateral heterogeneity of a medium, which is not always true in actual radiotherapy with protons and ions. This work addresses a solution for the problem. We found approximate self-similarity of Gaussian distributions, with which Gaussian beams can split into narrower and deflecting daughter b...