background: tolnidamine-induced changes have been reported earlier on spermatogenesis, fertility and sperm count in rat, rabbit and langur monkey. the aim of this study is to assess the response of these aspects to tolnidamine in the laboratory mouse. materials and methods: adult male mice (12-14 weeks old) of parkes (p) strain were used in the present study. all the animals were divided into f...

Background This study explored the possible role of FGF23 in pediatric hypercalciuria. Methods Plasma FGF23 was measured in 29 controls and 58 children and adolescents with hypercalciuria: 24 before treatment (Pre-Treated) and 34 after 6 months of treatment (Treated). Hypercalciuric patients also measured serum PTH hormone, 25(OH)vitD, phosphate, calcium, creatinine, and 24 h urine calcium, p...

Background Little is known about the efficacy of booster COVID-19 vaccination in rituximab (RTX)-treated patients with autoimmune inflammatory rheumatic diseases (AIIRD). Objectives To estimate breakthrough infection rate AIIRD treated RTX compared to other therapies and immunocompetent controls. Methods This observational multi-center study investigated humoral response (anti-S1/S2 IgG) BNT162...

Background: Kidney disorders are serious outcomes of diabetes, resulting in renal ailments. This study seeks to provide an alternative treatment for the disorder through the use of medicinal plants that offer renal protection and ameliorate the deleterious effect of diabetes. Methods: Thirty rats were divided into six groups of five and hyperglycemia was induced by intraperitoneal injection ...

Diabetes mellitus is a chronic disease which affects the healing ability of the pulp and periodontium. The aim of the present study was to assess the histopathologic response of dental pulp to pulp capping using MTA or CEM cement in diabetic rats. Thirty two Wistar male rats aged between 8 and 10 weeks (weight: 200-250g) were divided into two groups of diabetic (n=16) and healthy (n=16) animals...

Coating performance is greatly influenced by the properties of the wood substrate. This study was focused on evaluating the performance of coatings on both preservative- and thermally-treated wood. A number of commercially formulated semi-transparent stains Alkyd, Alkyd-Acrylic and PU were applied on four different types of preservative treated and heat-treated wood and their performances were ...

PURPOSE The tyrosine kinase inhibitors sorafenib and sunitinib have efficacy in several types of cancer. Recent studies indicate that these agents affect the immune system. The way it affects the immune response to influenza vaccination is unknown. The aim of this study was to elucidate the specific immune response to seasonal flu vaccination in cancer patients treated with sunitinib or sorafen...

Effects of norepinephrine infusion on rectal temperature, plasma free fatty acids (FFA) concentration and its turnover rate were studied in rats treated chronically with norepinephrine, thyroxine, or both. Chronic treatments with these hormones resulted in greater increases in rectal temperature and FFA turnover rate in response to norepinephrine as compared with the alterations in controls. No...

Progressive loss of muscle and function is associated with significant fibrosis in Duchenne muscular dystrophy (DMD) patients. Halofuginone, an analog febrifugine, prevents various animal models, including those dystrophies. Effects (+)/(?)-halofuginone enantiomers on motor coordination diaphragm histopathology mdx mice, the mouse model for DMD, were examined. Four-week-old male mice treated ra...