This study evaluated the utility of combinational therapy, coupling delayed posttraumatic hypothermia with delayed FK506 administration, on altered cerebral vascular reactivity, axonal injury, and blood-brain barrier (BBB) disruption seen following traumatic brain injury (TBI). Animals were injured, subjected to various combinations of hypothermic/FK506 intervention, and equipped with cranial w...

Juvenile traumatic brain injury (TBI) leaves survivors facing a potential lifetime of cognitive, somatic and emotional symptoms. A recent study published in Experimental Neurology (Kamper et al., 2013) explored the chronic consequences of focal brain injury induced in the juvenile animal, extending their previous observations out to 6months post-injury. The results demonstrate transient, persis...

working memory impairment is one of the most important cognitive deficits in patients with mild traumatic brain injury that affect mental health status even in the early stages of the disease. the purpose of this study was to evaluate the correlation between the working memory and mental health status in traumatic brain injury (tbi) patients. this cohort study was performed on 50 tbi patients a...

Traumatic brain injury (TBI), which results from an outside force causing mechanical disruption of brain tissue, is potentially life-threatening and therefore a critical public health problem throughout the world. In the USA, approximately 1.7 million individuals per year sustain a TBI, and about 43% of patients hospitalized because of TBI develop long-term physical disability as well as psycho...

Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries. This study examined the role of melatonin receptors in the neuroprotective effects of estrogen. Materials and Methods: Seventy female ovariectomized Wistar rats were divided in...

objective: this study was designed to examine the effects of human umbilical cord matrix stemcell (hucmsc) administration in rats for 6 week after traumatic brain injury (tbi). materials and methods: adult male wistar rats (n = 30) were injured with controlled cortical impact device and divided into three groups. the treatment groups (n = 10 each) were injected with 2 × 106 (2 milion) intraveno...

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play an essential role in homeostasis and diseases central nervous system. We hypothesize that microglia may a beneficial or detrimental TBI depending on their state activation duration. In this study, we evaluated whether results spatiotemporal change phenotype it affects sensory-motor learning memory functions ...

objective(s) clinical studies of treating traumatic brain injury (tbi) with autologous adult stem cells led us to examine the impression of a combination therapy. this was performed by intravenous injection of human umbilical cord matrix stem cell (hucmsc-wharton,s jelly stem cell) with bone marrow cell mobilized by granulocytecolony stimulating factor (g-csf) in rats injured with cortical comp...

Traumatic brain injury (TBI) leads to important and deleterious neuroinflammation, as evidenced by indicators such as edema, cytokine production, induction of nitric oxide synthase, and leukocyte infiltration. After TBI, cerebral vascular endothelial cells play a crucial role in the pathogenesis of inflammation. In our previous study, we proved that simvastatin could attenuate cerebral vascular...

traumatic brain injury (tbi) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. the use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of tbi. in the present study, we surveyed the beneficial effec...