Tayefi-Nasrabadi H1, Khodarahmi R2 1. Assistant Professor, Department of Biochemistry, Faculty of Veterinary Medicine, Tabriz University 2. Assistant Professor, Department of Biochemistry, Faculty of Medicine, Kermanshah University of Medical Sciences Abstract Background: Because of the difficulty in measuring each antioxidant component separately and the interactions among different...

Babies with mitochondrial encephalomyopathies had higher ferritin levels than controls. Although plasma iron levels were simi lar in both groups, babies with mitochondrial encephalomyopathies had lower transferrin levels. Thiobarbituric acid reactive substances in plasma of babies with mitochondrial encephalomyopathies were higher thun in controls suggesting increased lipid oxidation. We s...

Our objective was to understand the mechanism through which cells that initially survive irradiation could acquire survival advantage. In this study, we show evidence that low-linear energy transfer c-radiation can induce telomerase enzyme activity in primary aortic endothelial cells, and that an upstream regulator, nuclear factor kappa B (NF-kB), controls this activation. Telomeric repeat ampl...

BACKGROUND Telomerase is a ribonucleoprotein that maintains chromosomal telomere length. Telomerase is not active in nonmalignant somatic cells, but is activated in most human cancers. Telomerase activity in easily obtainable body fluids that bathe tumors may be a useful cancer marker, especially when used in conjunction with conventional cytology. APPROACH Results from studies that assayed t...

Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not in somatic cells. However, hTR; the RNA component of telomerase; has been reported to be universally expressed in both cancerous and non-cancerous tissues. Tumour samples from 50 patients with primary invas...

Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in osteoclast differentiation. However, the role of miR-340 and MITF during osteoclast differentiation has not yet been clearly established. Tartrate-resi...