نتایج جستجو برای: translocation factor

تعداد نتایج: 881516  

Journal: :The Journal of clinical investigation 2014
Liang Shan Robert F Siliciano

Chronic immune activation is a key factor in HIV-1 disease progression. The translocation of microbial products from the intestinal lumen into the systemic circulation occurs during HIV-1 infection and is associated closely with immune activation; however, it has not been determined conclusively whether microbial translocation drives immune activation or occurs as a consequence of HIV-1 infecti...

Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70...

Urban soil pollution has become a major concern in megacities around the world. Due to their non-degradable characteristic, toxic metals are among the most notorious pollutants. In this study determination of total and bioavailable fraction of toxic metals Ni, Cu, Cr, Zn, Co, Cd, Pb and Mn, in surface soils of district 16th in Tehran municipality is considered. Furthermore, metals uptake potent...

Journal: :RNA 2009
Andreas Savelsbergh Marina V Rodnina Wolfgang Wintermeyer

Elongation factor G (EF-G) promotes the translocation step in bacterial protein synthesis and, together with ribosome recycling factor (RRF), the disassembly of the post-termination ribosome. Unlike translocation, ribosome disassembly strictly requires GTP hydrolysis by EF-G. Here we report that ribosome disassembly is strongly inhibited by vanadate, an analog of inorganic phosphate (Pi), indic...

Journal: :Molecular and cellular biology 2008
Vigdis Sørensen Yan Zhen Malgorzata Zakrzewska Ellen Margrethe Haugsten Sébastien Wälchli Trine Nilsen Sjur Olsnes Antoni Wiedlocha

Exogenous fibroblast growth factor 1 (FGF1) signals through activation of transmembrane FGF receptors (FGFRs) but may also regulate cellular processes after translocation to the cytosol and nucleus of target cells. Translocation of FGF1 occurs across the limiting membrane of intracellular vesicles and is a regulated process that depends on the C-terminal tail of the FGFR. Here, we report that t...

Journal: :Cell 2006
Yan Qin Norbert Polacek Oliver Vesper Eike Staub Edda Einfeldt Daniel N. Wilson Knud H. Nierhaus

The ribosomal elongation cycle describes a series of reactions prolonging the nascent polypeptide chain by one amino acid and driven by two universal elongation factors termed EF-Tu and EF-G in bacteria. Here we demonstrate that the extremely conserved LepA protein, present in all bacteria and mitochondria, is a third elongation factor required for accurate and efficient protein synthesis. LepA...

2016
Yanliang Jin Xingwei Wang Shaoyan Hu Jingyan Tang Benshang Li Yihuan Chai

The t(12;21)(p13;q22) ETV6-RUNX1 gene fusion is one of the most common chromosomal translocation in childhood acute lymphoblastic leukemia (ALL). It is associated with favorable prognosis. The identification of the genomic sequence of the breakpoint flanking regions of the ETV6-RUNX1 translocation should be the best strategy to monitor minimal residual disease (MRD) in patients with ETV6-RUNX1-...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
K T Shaw A M Ho A Raghavan J Kim J Jain J Park S Sharma A Rao P G Hogan

The immunosuppressive drugs cyclosporin A and FK506 interfere with the inducible transcription of cytokine genes in T cells and in other immune cells, in part by preventing the activation of NF-AT (nuclear factor of activated T cells). We show that transcription factor NFAT1 in T cells is rapidly dephosphorylated on stimulation, that dephosphorylation occurs before translocation of NFAT1 into t...

2017
Liliana Villalon Marta Mamani Felix E. Romanini Antonio Catalan Alejandro Berra

Purpose: To evaluate nuclear NF-kB translocation in minor salivary glands (mSG) of human primary Sjögren Syndrome (pSS). Methods: Lip biopsies’ mSG were done in 24 female patients with pSS from the Rheumatology Service of Rivadavia Hospital. Glands were stained with H&E and immunostained for NF-kB. Specimens were classified according to the Chisholm and Masson score. Results: The biopsies (H&E ...

Journal: :journal of sciences islamic republic of iran 0

the most significant complication of pregnancy is recurrent miscarriage. numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects. cytogenetic evaluation of couples with recurrent pregnancy losses is performed on the basis of g-banding technique only after other possible et...

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