Background and aimsApolipoprotein (apo) C1 is a 6.6 kDa protein associated with HDL VLDL. ApoC1 alters triglyceride clearance, it also favors cholesterol accumulation in HDL, especially by inhibiting CETP human plasma. Apart from studies mice, which lack CETP, the impact of apoC1 on atherosclerosis animal models expressing like humans, not known. This study aimed at determining net effect rabbi...

Cre recombinase is extensively used to engineer the genome of experimental animals. However, its usefulness is still limited by the lack of an efficient temporal control over its activity. We have recently developed a conceptually new approach to regulate Cre recombinase, that we have called Dimerizable Cre or DiCre. It is based on splitting Cre into two inactive moieties and fusing them to FKB...