The transdermal delivery system of nutrients, cosmetics, and drugs is particularly attractive for painless, noninvasive sustainable release. Recently, atmospheric pressure plasma techniques have been great interest to improve the drug absorption rate in delivery. Currently, plasma-mediated changes lipid composition stratum corneum are considered a possible mechanism increase permeability. Never...

Rotigotine, a nonergot dopamine agonist, has been developed as a novel transdermal formulation. The rotigotine transdermal patch has received EMA and FDA marketing authorization for the treatment of adult patients with early or advanced Parkinson’s disease or with moderate-to-severe restless legs syndrome (RLS). This review comprises an overview of the pharmacokinetics, the pharmacodynamics and...

      The present study was performed to explore the matrix property of Ficus glomerata fruit mucilage for making transdermal patches. The mucilage was evaluated for its physicochemical properties. Various transdermal patches of indomethacin were prepared by solvent evaporation technique using different proportions of F. glomerata fruit mucilage. The compatib...

background and aims: one of the problems with the implementation of spinal anesthesia is not to achieve an appropriate sensory level and sensory level decline before the end of operation that can cause pain and stress for the patient and surgeon dissatisfaction.                                                                                              in this study, the effects of transdermal...

Imperfect use of contraceptive methods notably increases the likelihood of pregnancy. One means of improving user adherence with hormonal contraception is to minimize the dosing schedule. Two forms of hormonal contraceptive have currently achieved this goal: the transdermal patch and the vaginal ring. The first and only transdermal contraceptive patch to receive worldwide regulatory approval (e...

BACKGROUND Transdermal delivery of contraceptives offers several advantages over combined oral contraceptives (COCs), including effective absorption and the provision of relatively constant serum concentrations. Ethinyl estradiol (EE) and the progestin gestodene are well-absorbed through the skin and, therefore, well-suited for use in a transdermal contraceptive patch. OBJECTIVE The objective...

Circadian and meal effects on nicotine kinetics determine in part blood nicotine concentrations and in doing so may influence cigarette smoking behavior throughout the day. We have shown previously that nicotine clearance varies by approximately 17% (from peak to through) due to diurnal factors throughout the day and that meals increase nicotine clearance by about 42%. Until now pharmacokinetic...

This study summarizes the recent progress in thermoplastic drawing of bulk metallic glasses. The integration with templated embossing enables fabrication arrays high-aspect-ratio nanostructures whereas earlier methodologies are limited to a single fiber. two-step can produce glass structures such as, vertically aligned nanowires on substrates, nanoscale tensile specimens, hollow microneedles, h...

BACKGROUND To compare oral and transdermal delivery systems in domains of lipid effects; cardiovascular, inflammatory, and thrombotic effects; effect on insulin-like growth factor, insulin resistance, and metabolic syndrome; sexual effects; metabolic effects including weight; and effects on target organs bone, breast, and uterus. METHODS Review of the literature 1990-2010. Studies selected on...