Modifications in the structure of a 260 bp DNA (hlyM) fragment from Escherichia coli caused by interaction with Pd(II) and Pt(II) complexes were studied. Cisplatin and transplatin [cis- and trans-PtCl2(NH3)2 respectively], Pt2Cl2(Spym)4 (Spym = 2-mercaptopyrimidine anion), Pd-famotidine and Pt-famotidine were incubated with DNA for 24 h at 37 degrees C and then observed with an atomic force mic...

The crystal structure of molybdenum triplatinum tetrasilicide, MoPt(3)Si(4), determined previously from powder diffraction data [Joubert et al. (2010 ▶). J. Solid State Chem.183, 173-179], has been redetermined using a single crystal synthesized from the elements by high-frequency melting. The redetermination provides more precise geometrical data and also anisotropic displacement parameters. T...

To determine structure-optical property relationships in asymmetric platinum acetylide complexes, we synthesized the compounds trans-Pt(PBu3)2(C[triple bond]CC6H5)(C[triple bond]C-C6H4-C[triple bond]CC6H5) (PE1-2), trans-Pt(PBu3)2(C[triple bond]CC6H5)(C[triple bond]C-C6H4-C[triple bond]C-C6H4-C[triple bond]CC6H5) (PE1-3) and trans-Pt(PBu3)2(C[triple bond]C-C6H4-C[triple bond]CC6H5)(C[triple bon...

In the mononuclear title compound, trans-[PtCl2(C19H17P)2], the slightly distorted square-planar coordination sphere of the Pt(II) atom is occupied by two benzyl-diphenyl-phosphane ligands and two chloride atoms in a mutually trans geometry. The effective cone angles for the two phosphane ligands are 160 and 169°. C-H⋯Cl inter-actions generate infinite long chains along [01-1]. Additional C-H⋯π...

The reduction of the Pt(IV) complexes [PtCl4(bipy)], [PtCl4(dach)] and [PtCl4(en)] by glutathione (GSH), L-cysteine (L-Cys) and L-methionine (L-Met) was investigated by stopped-flow spectrophotometry at pH 2.0 (in 0.01 M perchloric acid) and at pH 7.2 (in 25 mM Hepes buffer). Kinetic measurements were performed under pseudo-first order conditions with an excess of the reducing agent. The order ...

The cover picture shows phosphanylthiolate ligand coordination on a platinum(II) center to give only the bischelate cis-P,P isomer when the ligand/Pt ratio is 2, whereas a trinuclear unexpected complex is achieved with a ligand/Pt ratio of 1. Here, the synthesis and structural determination is combined with density functional theory (DFT) calculations to rationalize the reaction mechanistically...

Invited for this month's cover picture are the groups of Prof. Alfonso Polo and Dr. Albert Poater at the Universitat de Girona, as well as their collaborators from the Universitat Autònoma de Barcelona and the Institute of Chemical Research of Catalonia. The cover picture shows phosphanylthiolate ligand coordination on a platinum(II) center to give only the bischelate cis -P,P isomer when the l...

The reaction of tetrapyrazine Pt(II) with adenine under basic conditions yielded two products both disubstituted by adenine and bound in all cases to the N-9 nitrogen of adenine. Crystals amenable to X-crystallographic analysis were obtained for one product which was consequently identified as trans-[Pt(II)(N9-adeH)2(pz)2](NO3)(4).H2O. The other product, though, was identified as the cis isomer...

Photoactivatable Pt diazido complexes have unusual photobiologic properties. We show here that trans, trans,trans-[Pt(N3)2(OH)2(py)(NH3)] complex 3 is a potent photoactivated cytotoxin toward human cancer cells in culture, with an average IC50 value in 13 cell lines of 55 28 mmol/L after 30 minutes (0.12 mW/cm) photoactivation with UVA, although visible light was also effective. Photoactivated ...

Binding to plasma proteins is one of the major metabolic pathways of metallodrugs. In the case of platinum-based anticancer drugs, it is the interaction with serum albumin that affects most strongly their in vivo behavior. Since both the configuration, i.e. cis-trans-isomerism, and the nature of leaving groups have an effect on the reactivity of Pt(II) coordination compounds toward biomolecules...