Arising in Europe the early 1990s, content and language integrated learning (CLIL) has become a popular educational approach. CLIL involves dual focus on with an additional used as medium of instruction. Although received much attention spread widely around world, there is limited discussion that critically examines relation to its core construct integration between learning. In particular, phr...

Due to their pivotal role in extender unit selection during polyketide biosynthesis, acyltransferase (AT) domains are important engineering targets. A subset of assembly line polyketide synthases (PKSs) are serviced by discrete, trans-acting ATs. Theoretically, these trans-ATs can complement an inactivated cis-AT, promoting introduction of a noncognate extender unit. This approach requires a be...

Trypanosoma cruzi currently infects 18 million people, and 30% of those infected develop a chronic inflammatory process that causes significant morbidity or mortality. The major histocompatibility complex class II (MHC-II)-restricted T-cell response is critical to the control of the infection and to the ensuing inflammatory pathology. The specific epitopes or major antigens of this response hav...

The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.

Results Findings revealed six themes: Knowticing; Getting a doctor; Trans‐action; Taleoring care; Experiencing vulnerability and Transporting: facilitating comfort and control. Three narrative aspects representing advanced practice were described: Rescue; Recognition and Responsibility; and Respect. The stories were of complex care situations relating to diverse areas of work highlighting criti...

Stilbene derivatives, which are resveratrol (3,4',5-trihydroxy-trans-stilbene) oligomers ranging from monomer to tetramer, isolated from Dipterocarpaceae plants were tested for their inhibitory effects against murine tyrosinase activity. The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that...