نتایج جستجو برای: tp53 polymorphism
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The p53 protein is at the center of cell regulatory pathways influencing transcription and activity of several replication and transcription factors. In exon 4 of the gene TP53, a codon 72 polymorphism causing an Arg/Pro substitution has been reported in breast and other cancers. This substitution is in the putative SH3 binding domain of p53 protein, influencing binding capacity and thereby fun...
background : gastric cancer as the fourth most frequent malignancy worldwide was known to have the highest rate among cancer-related disorders in ardabil province. the product of tp53 gene regulated the cell cycle process and acts as a tumor suppressor factor. the polymorphism p53 arg72pro (rs1042522) has been reported to be associated with many type of cancers. the purpose of the present stu...
2.Merril, C.R., D. Goldman, S.A. Sedman and M.H. Ebert. 1981. Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 211:1437-1438. 3.Sheffield, V.C., J.S. Beck, A.E. Kwitek, D.W. Sandstrom and E.M. Stone. 1993. The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions. G...
TP53 acts as a tumor suppressor in cancer. It induces cell cycle arrest or apoptosis in response to cellular stress and damage. p53 gene alteration could cause uncontrolled cell proliferation.In the present study, we used TP53 gene as the seed in the construction of a protein-protein functional association network to identify genes that might involve in tumorgenesis process with TP53. TP53 prot...
سابقه و هدف: سرطان پستان، شایعترین سرطان در زنان است که ژن سرکوبگر توموری tp53 نیز از فراوانترین ژنهای تغییر یافته در سرطانهای انسانی می باشد. ارزیابی دقیق جهش های ژن tp53 در مبتلایان سرطان می تواند در تشخیص ، پیش آگهی یا درمان اهمیت داشته باشد. این مطالعه به منظور شناسایی جهشهای این ژن در مبتلایان سرطان پستان انجام شد. مواد و روش ها: در این مطالعه توصیفی، تعداد 102 نمونه توموری از زنان آذ...
Nonsynonymous TP53 exon 4 single-nucleotide polymorphism (SNP), R72P, is linked to cancer and mutagen susceptibility. R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. Myelodysplastic syndrome (MDS) with chromosome 5q deletion is characterized by erythroid hypoplasia arising from lineage-specific p53 accumulation resulting from ribosoma...
BACKGROUND Risk factors for adult glioma in the San Francisco Bay Area include well-known demographic features such as age and race/ethnicity, and our previous studies indicated that these characteristics are associated with the TP53 mutation status of patients' tumors. We enlarged our study to assess the relationships of risk factors with TP53 as well as epidermal growth factor receptor (EGFR)...
Disruption or loss of tumor suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies. Other members of the p53 family have been identified. One member, p73, not only shares a high degree of similarity with p53 in its primary sequence, but also has similar functions. Like p53, p73 can bind to DNA and activate transcription. Using PC...
This study was designed to define the potential clinical relevance of identifying alterations affecting p53 pathway in bladder cancer and to test a new, low-cost, high-throughput, and array-based TP53 sequencing technology. Tumor samples from 140 evaluable patients with bladder cancer were analyzed with two methods to detect TP53 gene mutations, including single-stranded conformational polymorp...
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