there is considerable agreement among linguists that thematic analysis offers writers insights into manuscripts that may be rejected by international journals due to thematic organization problems. whereas many comparative studies have provided valuable information about thematic progression (tp), the role of peripheral themes (pts) has almost been neglected. using the revised model of the tp p...

Two-photon (TP) microscopy has an advantage for live tissue imaging which allows a deeper tissue penetration up to 1 mm comparing to one-photon (OP) microscopy. While there are several OP fluorescence probes in use for pancreatic islet imaging, TP imaging of selective cells in live islet still remains a challenge. Herein, we report the discovery of first TP live pancreatic islet imaging probe; ...

The effects of early testosterone propionate (TP) treatment on the adult sexual behavior of hamsters were investigafed in two experiments. In Expt. I, mJe and female pup3 were injected with oil vehicle or 1, 5, 10, 50, 100, or 250 gg of TP 24 hr after birth. In EXPC. II, males and females received ejther oil or 10 pg of TP on the day of birth (Day l), Day 3, Day 5, Day 7, or Day 9. At 70 days o...

OBJECTIVE Thymidine phosphorylase (TP) reportedly promotes endothelial cell migration and induces heme oxygenase (HO)-1 expression. However, its effect on vascular smooth muscle cells (VSMCs) is poorly understood. In this study, we examined the effect of TP on VSMCs in vitro and in vivo. METHODS AND RESULTS Phagemid vector encoding human TP gene was transfected into rat VSMCs, and a clone ove...

These studies were undertaken to determine the potential role of thromboxane receptors (TP) in bladder cancer. The data reported herein show that expression of the TP-beta receptor protein is increased in tissue obtained from patients with bladder cancer and associated with a significantly poorer prognosis (P < 0.005). Bladder cancer cell lines express the TP-beta isoform, unlike immortalized n...

The guanosine analogs BMS-200475 and lobucavir have previously been shown to effectively suppress propagation of the human hepatitis B virus (HBV) and woodchuck hepatitis virus (WHV) in 2.2.15 liver cells and in the woodchuck animal model system, respectively. This repression was presumed to occur via inhibition of the viral polymerase (Pol) by the triphosphate (TP) forms of BMS-200475 and lobu...

OBJECTIVE To evaluate the predictive value of tumor volume (TV), tumor percentage (TP), and number of tumor foci (NF) in patients with prostate cancer. The prognostic relevance of TV, TP, and NF as predictors of biochemical recurrence (BCR) following radical prostatectomy (RPE) is controversial. PATIENTS AND METHODS The cohort consisted of 758 referred subjects who underwent RPE between 2000 ...

Ductus arteriosus (DA) closure follows constriction and remodeling of the entire vessel wall. Patent ductus arteriosus occurs when the DA does not close after birth, and this condition is currently treated using cyclooxygenase inhibitors. However, the efficacy of cyclooxygenase inhibitors is often limited. Our previous study demonstrated that low-dose thromboxane A2 receptor (TP) stimulation co...

Pregnant rats were injected with 4 mg of testosterone propionate (TP) from days 15 to 22 of pregnancy or a single dose of 4 mg TP on day 17 or 21 of pregnancy. Female offspring treated with TP or the vehicle prenatally were sacrificed at 90 days of age. The volume of the cluster of intensely stained neurons in the medial preoptic area, the "sexually dimorphic nucleus of the preoptic area" (SDN-...

Chronic hepatitis B (CHB) is a chronic inflammatory viral disorder. Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarisation and that increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. Impaired autonomic function has been describe...