Letters an unusual case of localised hypertrichosis editor Topical testosterone is now a widely used mode of testosterone replacement therapy. It is well reported that transcutaneous absorption of testosterone may lead to hirsuitism and virilisation. 1,2 We report an interesting case of localised hypertrichosis on the forearm of a female patient and postulate that this was the result of acciden...

OBJECTIVE To determine whether topical menthol 6% gel will relieve a migraine attack. MATERIALS AND METHODS A single-center, open-label pilot trial of 25 patients with at least 1 year of diagnosed episodic migraine and <15 headache days per month. Patients treated one migraine attack with STOPAIN topical menthol 6% gel to skull base within 2 h of headache onset. Headache pain severity was ass...

BACKGROUND Topical preparations are a common treatment for superficial acute wounds, which at the least do not interfere with healing and ideally result in enhanced wound healing irrespective of microbial colonization. OBJECTIVE To examine the effects of a topical antimicrobial gel and its vehicle on the wound healing of standardized, superficial abrasions. METHODS Thirty-three healthy volu...

Background: The stratum corneum (SC) forms a difficult physical barrier for drugs to pass through the skin. Several strategies were developed to overcome this barrier. Optimization of topical drug formulations by selected excipients may facilitate the penetration of drugs through the SC into the viable skin cells and ultimately into the systemic circulation. Methods: Here, both the influence of...

The objective of present study was to develop nonionic surfactant vesicles of proteolytic enzyme serratiopeptidase (SRP) by adapting reverse phase evaporation (REV) technique and to evaluate the viability of SRP niosomal gel in treating the topical inflammation. The feasibility of SRP niosomes by REV method using Span 40 and cholesterol has been successfully demonstrated in this investigation. ...

Objective: Sulphur mustard (SM), chemically 2,2'-dichloro diethyl sulphide, is an incapacitating and extremely toxic chemical warfare agent, and causes serious blisters on contact with human skin. SM forms sulphonium ion in the body that alkylates DNA and several other macromolecules, and induces oxidative stress. The aim of this study was to evaluate the protective effect of Aloe vera L. gel a...

Rosacea is characterized by transient or persistent erythema, telangiectasia, papules and pustules primarily affecting the central facial region. Recently brimonidine tartrate gel 0.33%has been approved for the topical treatment of persistent facial erythema of rosacea (1). Allergic blepharitis caused by brimonidine in patients treated with brimonidine tartrate 0.33% eye drops has been document...

Topical preparations are dosage forms applied to the skin for local therapy. These topical contain several types of bases that used drug formulations. This review aimed determine type base is effective and widely in basil leaf function as antioxidants, antibacterial agents, wound healing. The research method comparative, namely, reviewing articles on formulations products with various concentra...