In order to investigate how glucocorticoids affect the expression of secretory leukocyte peptidase inhibitor (SLPI), which is overexpressed in a variety of cancers, clobetasol was added to cell culture medium of U937 cells and the SLPI mRNA levels were examined. The in vitro effect of the treatment on SLPI expression was detected by reverse transcriptase-polymerase chain reaction. Clobetasol tr...

The Aloe vera (L.) Burman f. pulp extract (AE), obtained from the inner parts of leaves, is rich in polysaccharides, including glucomannans, acemannans, pectic compounds, cellulose, and hemicelluloses; acemannan glucomannan are considered two main components responsible for most plant’s therapeutical properties. Besides having anti-inflammatory activity, these polysaccharides accelerate wound h...

Background: Recent findings establish the 308 xenon chloride (XeCl) excimer laser (EL) to be a new option in the area of UVB phototherapy. Since the EL enables high radiant exposure of narrow-band (NB) UVB and precise targeting of affected skin, it appears to be a promising treatment for the prurigo form of atopic dermatitis (AD). Objectives: To investigate the efficacy and safety of the excime...

oral lichen planus (olp) is a chronic inflammatory disease of oral mucosa, with an immunological origin. atrophic/erosive olp needs appropriate treatment, due to the pain and malignancy potential. topical corticosteroids are the most effective drug therapy and mouthwashes are more effective topical dosage forms for this purpose. however, at present there are no corticosteroid mouthwashes availa...

To cite: Ranpara MP, Yesudian PD. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015211792 DESCRIPTION A 69-year-old woman presented to the emergency department with a painful rash of 5 weeks duration. The rash started as two discrete erythematous plaques on the left medial malleolus and was treated as cellulitis by her general practitioner. Despite antibiotic t...