Allergic asthma represents an important public health issue, most common in the paediatric population, characterized by airway inflammation that may lead to changes in volatiles secreted via the lungs. Thus, exhaled breath has potential to be a matrix with relevant metabolomic information to characterize this disease. Progress in biochemistry, health sciences and related areas depends on instru...

The recent development in high-resolution mass spectrometry (MS) has afforded powerful analytical equipments, e.g., ultra performance liquid chromatography coupled to time-offlight mass spectrometry (UPLC TOFMS), for rapid qualitative analysis of samples as complex mixtures in biomedical research. This is especially beneficial for the research fields as untargeted metabolomics and pharmaceutica...

The critical importance of employing sound statistical arguments when seeking to draw inferences from inexact measurements is well-established throughout the sciences. Yet fundamental statistical methods such as hypothesis testing can currently be applied to only a small subset of the data analytical problems encountered in LC/MS experiments. The means of inference that are more generally emplo...

Title of Document: PROBING THE IGNITION MECHANISM OF ALUMINUM NANOTHERMITES Snehaunshu Chowdhury, Ph.D., 2012 Directed By: Professor Michael R. Zachariah, Department of Mechanical Engineering, Chemistry and Biochemistry Nanothermites are defined as intimate mixtures of metal and metal oxidizer particles usually below 100 nm in diameter. They belong to a class of energetic materials which have b...

In any Hadamard multiplexing technique, discrepancies between the intended and the applied encoding sequences may reduce the intensity of real spectral features and create discrete, artificial signals. In our implementation of Hadamard transform time-of-flight mass spectrometry (HT-TOFMS), the encoding sequence is applied to the ion beam by means of an interleaved comb of wires (Bradbury-Nielso...

An ion mobility/mass spectrometry technique has been developed to record mass-resolved ion mobility distributions for multiple ions simultaneously. The approach involves a new instrument that couples an electrospray ion source to an injected-ion drift tube/time-of-flight mass spectrometer. Individual components in a mixture of ions are separated by mobility differences in a drift tube and subse...