A randomized, double-masked, crossover clinical trial was carried out to evaluate whether lovastatin therapy (60 mg daily) affects the initiation of oxidation of low density lipoprotein (LDL) in cardiac patients on alpha-tocopherol supplementation therapy (450 IU daily). Twenty-eight men with verified coronary heart disease and hypercholesterolemia received alpha-tocopherol with lovastatin or w...

Vitamin E (α-tocopherol) is a natural antioxidant very useful for preventing the harmful effects of UV sun rays as skin aging and cancers. In this study, different MLV formulations were made using egg lecithin and varying molar ratios of α-tocopherol and/or cholesterol, and their encapsulation efficiencies were determined. The best liposomal product was incorporated into a carbomer 980 gel. The...

Background: Little is known about factors that modulate dietary -tocopherol bioavailability. Objectives: The study aimed to assess the efficacy of vitamin E–fortified apples as a low-fat vitamin E delivery system, the influence of fat on vitamin E absorption, and human vitamin E requirements by using plasma -tocopherol kinetics at a dosage of -tocopherol

Tocopherol-associated protein (TAP) was expressed in mouse mast cells. TAP was predominantly localized in the cytoplasm, and the subcellular localization was not changed by alpha-tocopherol. The results suggest that the physiological role of TAP in mast cells is not regulation of tocopherol function but an as-yet-unidentified activity.

alpha-Tocopherol belongs to the group of vitamin E vitamers. Recent years findings indicate that alpha-tocopherol is more than just a simple fat-soluble anti-oxidant as it was found that it can also regulate gene expression. From all vitamin E vitamers human body preferentially retains alpha-tocopherol, but the reasons for this preference are still elusive. Different studies indicated that huma...

OBJECTIVES This study sought to examine whether oral intake of alpha-tocopherol, an antioxidant, could improve endothelium-dependent vasorelaxation in patients with high remnant lipoproteins levels. BACKGROUND Remnant lipoproteins are known to be atherogenic and impair endothelium-dependent arterial relaxation, but the underlying mechanisms remain unclear. Oxidative stress is a common feature...

background: previous study by the authors showed that a-tocopherol prevents oxidative stress but would not improve depressed excretory variables in post-obstructed kidney (pok) after release of 24-h unilateral ureteral obstruction (uuo). this study is a supplementary investigation on the effects of a-tocopherol combined with an antagonist of angiotensin-ii type-1 (at1) receptor on renal dysfunc...

sesame (sesamum indicum l.) seed and oil have long been used widely as healthy foods to supply energy and prevent aging. some of the main active anti-oxidative constituents in sesame seeds are γ-tocopherol and phenols. the purpose of this study was to investigate the relationship between roasting temperature and time with γ-tocopherol and total phenolic compounds (tpc) of sesame seeds when roas...

Alpha-tocopherol content and production of malondialdehyde (MDA) was measured in liver, kidney, heart, lung, brain and skeletal muscle homogenates of control and hypoxic rats (following a 2-h-exposure to 200 mm Hg): the samples were incubated at 37 degrees C in air for 1 h. MDA production showed no relation with the content of alpha-tocopherol in control and hypoxic rats. In control animals, th...

Non-alcoholic fatty liver disease is the most common liver disorder in developed countries, and its incidence is increasing in all population groups. As an antioxidant, vitamin E is effective in the treatment of non-alcoholic fatty liver disease, although the mechanism is still unclear. Methionine-choline deficient Wistar rats (n = 5) used as an experimental model of non-alcoholic fatty liver d...