نتایج جستجو برای: tlr5

تعداد نتایج: 700  

Journal: :International journal of molecular medicine 2013
Monowar Aziz Shunji Ishihara Mesbah Uddin Ansary Hiroki Sonoyama Yasumasa Tada Akihiko Oka Ryusaku Kusunoki Yuji Tamagawa Nobuhiko Fukuba Yoshiyuki Mishima Tsuyoshi Mishiro Naoki Oshima Ichiro Moriyama Norihisa Ishimura Shuichi Sato Takafumi Yuki Kousaku Kawashima Yoshikazu Kinoshita

During intestinal inflammation, a variety of signaling events are activated to perform several cell functions. Although the distinct roles of these pathways have been elucidated, the effects of their crosstalk activities remain to be clarified. We evaluated the crosstalk between two evolutionary conserved cell signaling systems, toll-like-receptor (TLR) 5 and Notch1, in intestinal epithelial ce...

2014
S.C. Silva G.L. Baggio-Zappia M.K.C. Brunialti M.S.C. Assunçao L.C.P. Azevedo F.R. Machado R. Salomao

Recognition of pathogens is performed by specific receptors in cells of the innate immune system, which may undergo modulation during the continuum of clinical manifestations of sepsis. Monocytes and neutrophils play a key role in host defense by sensing and destroying microorganisms. This study aimed to evaluate the expression of CD14 receptors on monocytes; CD66b and CXCR2 receptors on neutro...

2017
Tianwen Xu Deqiang Fu Yi Ren Yijun Dai Jianguang Lin Liming Tang Jian Ji

Gastric cancer (GC) ranks the second prevalent cancer type and the second cancer-related death in China. However, the precise mechanisms of GC development remain poorly understood. Chronic infection with Helicobacter pylori is the strongest identified risk factor for GC. Toll-like receptor (TLR) genes, which play critical roles in Helicobacter pylori induced chronic inflammation, may also be im...

Journal: :Journal of immunology 2000
M Muzio D Bosisio N Polentarutti G D'amico A Stoppacciaro R Mancinelli C van't Veer G Penton-Rol L P Ruco P Allavena A Mantovani

Members of the Toll-like receptor (TLR) family probably play a fundamental role in pathogen recognition and activation of innate immunity. The present study used a systematic approach to analyze how different human leukocyte populations express specific transcripts for the first five characterized TLR family members. TLR1 was expressed in all leukocytes examined, including monocytes, polymorpho...

Journal: :Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2007
Brian C Peterson Brian C Small Lanie Bilodeau

The effects of GH on immune and endocrine responses to channel catfish challenged with the bacterium Edwardsiella ictaluri were examined. Catfish (11.7+/-1.0 g) treated with recombinant bovine growth hormone (rbGH) and challenged with E. ictaluri experienced similar mortality as control-exposed fish. Plasma activity of lysozyme was higher (P<0.01) in rbGH-exposed fish. Compared to day 0 control...

2017
Yang Xu Yuanyuan Chen Hu Liu Xiao Lei Jiaming Guo Kun Cao Cong Liu Bailong Li Jianming Cai Jintao Ju Fu Gao Yanyong Yang

It is urgently required to develop novel safe and effective radioprotectors to alleviate radiation damages. Recently, several toll like receptors (TLRs), including TLR2, TLR4, TLR5, TLR9, have been proved to exert protective effects against ionizing radiation. Due to different tissue-distribution and distinct functions of TLRs, we hypothesized that co-activation of multiple TLRs simultaneously ...

Journal: :The Journal of biological chemistry 2014
Anna Hanuszkiewicz Paula Pittock Fiachra Humphries Hermann Moll Amanda Roa Rosales Antonio Molinaro Paul N Moynagh Gilles A Lajoie Miguel A Valvano

Burkholderia cenocepacia is an opportunistic pathogen threatening patients with cystic fibrosis. Flagella are required for biofilm formation, as well as adhesion to and invasion of epithelial cells. Recognition of flagellin via the Toll-like receptor 5 (TLR5) contributes to exacerbate B. cenocepacia-induced lung epithelial inflammatory responses. In this study, we report that B. cenocepacia fla...

Journal: :European journal of gastroenterology & hepatology 2014
Christiane Barthel Marianne R Spalinger Jakob Brunner Silvia Lang Michael Fried Gerhard Rogler Michael Scharl

Recent studies have identified more than 160 inflammatory bowel disease susceptibility loci and provided evidence for genetic heritability in disease pathogenesis. Here we describe a case of a 47-year-old White woman suffering from Crohn's disease (CD), who had four children, two with CD and two with a factor V Leiden variation. We analysed the presence of single nucleotide polymorphisms in sev...

2010
Joëlle Rolli Noureddine Loukili Sandra Levrand Nathalie Rosenblatt-Velin Stéphanie Rignault-Clerc Bernard Waeber François Feihl Pal Pacher Lucas Liaudet

INTRODUCTION Systemic inflammation in sepsis is initiated by interactions between pathogen molecular motifs and specific host receptors, especially toll-like receptors (TLRs). Flagellin is the main flagellar protein of motile microorganisms and is the ligand of TLR5. The distribution of TLR5 and the actions of flagellin at the systemic level have not been established. Therefore, we determined T...

Journal: :Fish & shellfish immunology 2008
Lelania Bilodeau-Bourgeois Brian G Bosworth Brian C Peterson

Survivorship to ESC (enteric septicemia of catfish) varies among and within strains of commercially raised catfish, however the immunological basis for differences in susceptibility is not well-understood. We assessed the effect of pathogen challenge with Edwardsiella ictaluri on five genetic groups of catfish by measuring both phenotypic response (mortality, pathogen levels, specific growth ra...

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