In the course of lung cancer, normal cells are transformed into cancerous ones, and changes occur in microenvironment, including extracellular matrix (ECM), which is not only a scaffold for cells, but also reservoir cytokines, chemokines growth factors. Metalloproteinases (MMPs) among elements that enable ECM remodeling. The publication focuses on problem gene expression MMP2, MMP9 tissue inhib...

Background: Gliomas are primary cerebral tumors. Radiation therapy plays a key role in their treatment but with risk of toxicity associated the dose to and volume normal tissue that is irradiated. With its precision properties allowing for increased sparing healthy tissue, proton could be an interesting option this pathology. Methods: Two reviewers performed systematic review original papers pu...

In this article, we are collectively presenting case reports of 15 patients who developed pigmentary changes of the skin and mucus membrane during the course of chloroquine therapy for connective tissue disorders. These female patients developed hyper pigmentation of the skin, largely on the exposed parts of the body. The pigmentary changes varied from brownish/ grayish/ bluish-black in color, ...

Boron Neutron Capture Therapy (BNCT) is a binary therapy that promises to be suitable in treating many non-curable cancers. To that, the discovery of new boron compounds able accumulate selectively tumour tissue still required. Hypoxia, deficiency oxygen tumor tissue, great challenge conventional treatment cancer, because hypoxic areas are resistant anticancer treatments. 2-Nitroimidazole deriv...