objective(s) arsenic compounds are potent human carcinogen and produce a variety of stress responses in mammalian cells. recently sodium arsenite has been recommended to be used as anti malignancy drug by american food and drug administration (fda). in this study, we aimed to determine the apoptosis inducing effect of sodium arsenite on rat bone marrow mesenchymal stem cells exposed in vitro. m...

Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

background degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. the principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. to briefly review the lines of research and potential candidates for cell based therapies among r...

Tissue engineering skeletal muscle in vitro is of great importance for the production of tissue-like constructs for treating tissue loss due to traumatic injury or surgery. However, it is essential to find new sources of cells for muscle engineering as efficient in vitro expansion and culture of primary myoblasts are problematic. Mesenchymal stem cells may be a promising source of myogenic prog...

Objective Adult stem cells which are derived from different tissues, with their unique abilities to self-renew and differentiate into various phenotypes have the potential for cell therapy and tissue engineering. Human adipose tissue is an appropriate source of mesenchymal stem cells with wide differentiation potential for tissue engineering research. In this study isolated stem cells from hum...

background  the mammary gland in humans is a dynamic organ that undergoes significant developmental changes during pregnancy, lactation, and involution. stem cells derived from human breast milk possess the adult stem cell-like characteristics such as self-renewal, proliferative and differentiate potential. this source of stem cells avoids invasive procedures and the ethical controversy of embr...

Background: In this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. Materials and Methods: Human umbilical cord blood-derived mesenchymal stem cells were first cultured in Dulbecco’s modified eagle medium supplemented with 10% fetal bovine serum in a humidified incu...

objective(s) bone marrow is the traditional source of human multipotent mesenchymal stem cells (mscs), but adipose tissue appears to be an alternative and more readily available source. in this study, rat adipose-derived stem cells (adscs) were induced to differentiate into schwann-like cells and compared with rat bone marrow stem cells (bmscs) for their schwann-like cells differentiation poten...

objective(s) mesenchymal stem cells (mscs) are nonhematopoietic stromal cells that are capable of differentiating into and contribute to the regeneration of mesenchymal tissues. human mesenchymal stem cells (hmscs) are ideal targets in cell transplantation and tissue engineering. enhanced green fluorescent protein (egfp) has been an important reporter gene for gene therapy. the aim of this stud...