The recent discovery of H3K27me3 demethylases suggests that H3K27me3 may dynamically regulate gene expression, but this potential role in mammalian tissue homeostasis remains uncharacterized. In the epidermis, a tissue that balances stem cell self-renewal with differentiation, H3K27me3, occupies the promoters of many differentiation genes. During calcium-induced differentiation, H3K27me3 was er...

pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be genetic. the two significant features represented for stem cells, leading to distinguish them from other cell types are addressed as below: they can renew themselves besides the ability to differentiate into cells wi...

background: in most cases, prostatitis can be caused by a bacterial agent such as ureaplasma urealyticum. considering to the cumbersome of the culture method for the detection of ureaplasma species in clinical samples such as prostate; pcr method that is faster and more appropriate than the cultivation methods, can be utilized for the detection of u. urealyticum and u. parvum. pcr-rflp method c...

results migration of cells started on the fifth day. as a result of this migration, most cells were located on the surface of the scaffold and formed epiderm-like structure and some penetrated into the scaffold. by day 25, cells which had penetrated into the scaffold had various destinies such as becoming elongated spindle-shaped cells and creating blood vessel-like structures. conclusions adm ...

Macrophages are specialized cells that control tissue homeostasis. They include non-resident and tissue-resident macrophage populations which characterized by the expression of particular cell surface markers secretion molecules with a wide range biological functions. The differentiation polarization macrophages relies on specific growth factors their receptors. Macrophage-colony stimulating fa...

background and aims. well-differentiated chondrosarcoma and enchondroma are similar in histopathologic aspects; therefore, special methods should be used to make a distinction between these benign and malignant tumors. the aim of this study was to evaluate the efficacy of a histopathologic method in the long-term follow-up for differentiating these lesions. materials and methods. the medical re...

The efficiency of cell or tissue cultures is usually judged by how quickly confluence is reached within a Petri dish or on a scaffold. Growth factors and fetal bovine serum are employed to drive cultured cells from one mitosis to the next as quickly as possible. The tissue specific interphase is extremely short under these conditions, so that the degree of differentiation desired in tissue engi...