BACKGROUND Abdominal operations are followed by adhesions, a prevalent cause of abdominal pain, and the most frequent cause for bowel obstruction and secondary female infertility. This rat study addresses adhesion prevention capability of Adept(®), Interceed(®), Seprafilm(®), and a novel device, 4DryField(®) PH which is provided as powder and generates its effect as gel. METHODS Sixty-eight m...

Cells generate traction forces upon adhesion to the extracellular matrix as well as to neighboring cells. These forces are important for the growth and maintenance of adhesion structures such as focal adhesions and adherens junctions, and may play roles in tissue development. Here, we describe a method for measuring the tugging force transmitted across the cell-cell junction between two paired ...

BACKGROUND Arthrofibrosis in the suprapatellar pouch and anterior interval can develop after knee injury or surgery, resulting in anterior knee pain. These adhesions have not been biomechanically characterized. METHODS The biomechanical effects of adhesions in the suprapatellar pouch and anterior interval during simulated quadriceps muscle contraction from 0 to 90° of knee flexion were assess...

Abstract Asherman syndrome (AS) refers to the loss of endometrial stem cells and matrix hyperplasia caused by basal layer injury. Its common clinical manifestations include narrowing uterine cavity, reduction in menstrual volume, abdominal pain, amenorrhea, infertility. According cause AS, treatment includes a mechanical barrier functional recovery. Because recovery endometrium depends on regen...

Prehension is a complex function of the hand that gives it mechanical precision combined with a standard sensory pattern. The priority in soft tissue reconstruction for the upper extremity is to restore function. Significant injury to the upper extremity may result after trauma because of various etiologies. The timing and choice of soft tissue coverage for upper extremity defects warrant speci...

Cell motility necessitates the rapid formation and disassembly of cell adhesions. We have studied adhesions in a highly motile melanoma cell line using various biochemical approaches and microscopic techniques to image close adhesions. We report that WM-1617 melanoma cells contain at least two types of close adhesion: classic focal adhesions and more extensive, irregularly shaped adhesions that...

Intra-abdominal adhesions are almost inevitable after major abdominal surgery. Postoperative adhesions continue to be the major cause of small bowel obstruction and infertility. Peritoneal lesions caused by abrasion, ischemia, desiccation, infection, thermal injury and foreign bodies are the origin of adhesions. Fibrinous adhesions that develop within a few hours of operational trauma. This fib...

Failed rotator cuff repair may be caused by surgical complications, diagnostic errors, technical errors, failure to heal, and traumatic failure. Revision rotator cuff repair is made technically more difficult by poor tissue quality, tissue adhesions, and retained suture and suture anchor material. Historically, open revision rotator cuff repair yields inferior results compared with primary rota...

1. The acetone-soluble fat of tubercle bacilli produces a profound cellular reaction when injected into normal animals. The reaction involves every type of connective tissue cell. Hemorrhage, formation of adhesions and of tubercular tissue occur. The extent of the reaction is roughly proportional to the amount of material injected. 2. The reaction induced by the lipoid is much less extensive an...

A pattern of circular islands of adhesive substratum can be used to control cell shape and behaviour. We have shown previously that the proportion of Swiss 3T3 cells that synthesize DNA varies with the area of the island to which they are attached, within the range 500-5000 microns2. In this paper we investigate the cytoskeleton and adhesions of cells on islands using a variety of techniques in...