Alpha1-adrenoceptor-dependent proliferation of vascular smooth muscle cells (VSMCs) is strongly augmented by vascular injury, and may contribute to intimal growth and lumen loss. Because reactive oxygen species (ROS) are increased by injury and have been implicated as second messengers in proliferation of VSMCs, we investigated the role of ROS in catecholamine-induced VSMC growth. Rat aortae we...

BACKGROUND It is not known whether thromboxane A2 impairs adenosine triphosphate (ATP)-sensitive K channel function via increased production of superoxide in blood vessels and whether propofol as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor restores this modification. METHODS Rat aortas without endothelium were used for isometric force recording, measurements of mem...

Persistent pulmonary hypertension of newborn (PPHN) is associated with decreased NO release and impaired pulmonary vasodilation. We investigated the hypothesis that increased superoxide (O(2)(*-)) release by an uncoupled endothelial nitric oxide synthase (eNOS) contributes to impaired pulmonary vasodilation in PPHN. We investigated the response of isolated pulmonary arteries to the NOS agonist ...

knowledge of transport and degradation of polycyclic aromatic hydrocarbons (pahs) is important in assessing pah contamination of soils and water resources. the transport of naphthalene, anthracene, pyrene and phenanthrene was determined in a contaminated calcareous soil obtained from the shadegan wetland (khozestan, iran) considering a column study in laboratory conditions. the pahs were added ...

Thermal experiments (at 250-450 °C for 10-240 min) on fly ash from secondary copper smelting process (SeCu) were performed to study the polychlorinated naphthalene (PCN) formation in the post-zone of a secondary copper smelter. Unexpectedly high concentrations of PCNs were formed. Total PCN concentrations and toxic equivalents were 47-104 and 44-80 times higher than the initial concentration an...

The naphthalene dioxygenase (NDO) system catalyzes the first step in the degradation of naphthalene by Pseudomonas sp. strain NCIB 9816-4. The enzyme has a broad substrate range and catalyzes several types of reactions including cis-dihydroxylation, monooxygenation, and desaturation. Substitution of valine or leucine at Phe-352 near the active site iron in the alpha subunit of NDO altered the s...

The asymmetric unit of the title compound, C(24)H(22)O(4), contains two independent mol-ecules in both of which the naphthalene ring systems adopts a transoid arrangement. The dihedral angles between the naphthalene ring system in the two mol-ecules are 83.0 (1) and 89.0 (1)°. There are slight differences in the C(H(3))-O-C(H(2))-O- torsion angles of the eqivalent meth-oxy-meth-oxy groups. In t...

Naphthalene has been described as new class of potent antimicrobials against wide range of human pathogens. It occupies a central place among biologically active compounds owing to its varied and exciting antibiotic properties with less toxicity [1]. Numerous naphthalene containing antimicrobial drugs are existing like naftifine, nafacillin, terbinafine, tolnaftate, etc. that plays vital role a...

Cunninghamella elegans oxidized naphthalene to ethyl acetate-soluble and water-soluble metabolites. Experiments with [14C]-naphthalene indicated that 21% of the substrate was converted into metabolites. The ratio of organic-soluble metabolites to water-soluble metabolites was 76:24. The major ethyl acetate-soluble naphthalene metabolites were trans-1,2-dihydroxy-1,2-dihydro-naphthalene, 4-hydro...

The enzymes of naphthalene metabolism are induced in Pseudomonas putida ATCC 17484, PpG7, NCIB 9816, and PG and in Pseudomonas sp. ATCC 17483 during growth on naphthalene or salicylate; 2-aminobenzoate is a gratuitous inducer of these enzymes. The meta-pathway enzymes of catechol metabolism are induced in ATCC 17483 and PPG7 during growth on naphthalene or salicylate or during growth in the pre...