BACKGROUND Cadmium (Cd), a nonessential heavy metal, is a major environmental and public health concern. Oxidative stress plays an important role in Cd-induced kidney dysfunction. Tinospora cordifolia, a medicinal plant rich in phytochemicals, possesses antioxidant activity. The objective of the present study was to assess the protective effect of Tinospora cordifolia-stem methanolic extract (T...

The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potential of AETC or METC was determined by measuring the cytokine levels in the cultu...

Diabetic Neuropathy (DN) is one of the prevailing micro vascular complications diabetes which can be characterized by neuropathic pain. Streptozotocin (STZ) induced in rat has been increasingly used as a model painful diabetic neuropathy. STZ injection leads to neurotoxicity peripheral nerves that development Peripheral model. The present study was aimed at exploring protective role Tinospora c...

objective: the role of herbs against the free radicals have been put forth recently in combating many diseases. the aim of this study was to elucidate the in vitro capacity and in vivo antioxidant properties of sedimental extract of tinospora cordifolia (setc). materials and methods: setcwas subjected to in vitro chemical analysis such as 1,1-diphenyl-2-picrylhydrazyl (dpph), nitric oxide, hydr...

The present study was taken up to investigate the effect of petroleum ether extract of Tinospora cordifolia (Wild.) Miers, on depression in mice. The extract (50, 100 and 200 mg/kg, p.o.) was administered for 14 successive days to Swiss young albino mice (either sex) and evaluated for antidepressant-like activity using tail suspension test and forced swim test. Petroleum ether extract at all th...

Tinospora cordifolia (RTc) has already been reported to protect whole-body lethally irradiated mice. This study has focussed on certain aspects of immuno-competence, which are adversely affected by irradiation. This study included estimation of spleen size, cell count, DNA fragmentation and apoptosis in splenocytes. The adherence, spreading and phagocytic activities of macrophages were also ass...

The aim of the study was to evaluate anticancer activity methanol and aqueous extracts leaves Tinosporacordifolia Wild Miers against a Human Breast Carcinoma Cell line(MDAMB231) by MTT assay. coarse powder leaf were subjected Soxhletextraction microwave assisted extraction using water as solvent. IC50 values extract followed soxhlation found be 59.85μg/mL 249μg/mLrespectively in MDAMB231 cell...