alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by memory and cognitive dysfunction due to neuronal cell loss in higher brain centers. senile plaques containing amyloid β (aβ) are associated with this disease as well as a reduction in cholinergic neuron numbers. tacrine is a reversible cholinesterase inhibitor in clinical use to treat moderate forms of ad. chit...

BACKGROUND The immunosuppressive drug tacrolimus has the short-term effect of reducing proteinuria in patients with immunoglobulin A nephropathy (IgAN). Our study investigated the effects on proteinuria and kidney function after discontinuation of tacrolimus. METHODS Patients with biopsy-proven IgAN were included in the study and randomly divided into two treatment groups. There was a corresp...

AIMS Myocardial performance index (MPI), or Tei index, is a Doppler echocardiographic parameter defined as the sum of the isovolumic contraction and relaxation times divided by the ejection time. It is considered a reliable parameter for global left ventricular function. However, the interpretation of this index is not fully clear in diastolic dysfunction. We measured MPI in a pressure-overload...

OBJECTIVE To compare outcomes with the use of thyroid ala cartilage (TAC) and costal cartilage (CC) grafts in pediatric primary anterior laryngotracheoplasty (LTP). DESIGN Retrospective comparison study. SETTING Tertiary, academic children's hospital. PATIENTS Of 45 laryngotracheal operations performed between June 2001 and October 2008 for laryngotracheal stenosis, 29 were primary anteri...

Calcineurin inhibitors (CNIs) are maintenance immunosuppressive drugs that have been used as the main therapy for organ transplantation for many years. Of the CNIs, cyclosporine (CYA) and tacrolimus (TAC) are used in clinical practice. The CYA binding protein is cyclophilin and that of TAC is FK-binding protein (FKBP), but both drugs have same mechanism of action: the inhibition of interleukin ...

The rouge waves in an optically injected semiconductor lasers are receiving a lot of interest. In this work, the generating and controlling of the rogue waves in semiconductor lasers have been investigated. For this purpose, the laser’s rate equations are solved numerically in a specified time interval, then the field amplitude and the intensity versus time are calculated and analyzed. To solve...