The purpose of this study was to obtain a nicorandil pulsatile release tablet that has a well-regulated release lag time. When nicorandil is used as an antiangina drug, administration time control is important. A pulsatile release tablet is one of the effective approaches to modified release to reduce daily administration frequency. In this study, a pulsatile release tablet of nicorandil was fo...

The pole assignment method for non-delay multivariable systems has received a great deal of attention for designing feedback controllers to achieve desired objectives [1], [2]. Suh and Bien [3] have considered a root locus technique for linear systems with time-delay. Here is an attempt to present a pole assignment method for multi-input systems with input delay. The single-input system with de...

A problem of robust fault diagnosis of digital controlled continuous-time systems with uncertain time-varying input delay is studied in this paper. Two residual-based fault detection and isolation (FDI) schemes are proposed that are robust in terms of time-varying delays induced by the electronic devices and disturbances. The idea of both proposed methods is to transform the uncertainty caused ...

The robust stability analysis of asynchronous and uncertain sampled-data systems with constant incremental input delay is addressed in the looped-functional framework. These functionals have been shown to be suitable for the analysis of impulsive systems as they allow one to express discrete-time stability conditions in an affine way, enabling then the consideration of uncertain and time-varyin...

This work presents a new discrete-time adaptive-predictive control algorithm for a system with force disturbance and input delay. This scenario is representative of a mechatronic device for percutaneous intervention with pneumatic actuation and long supply lines which is controlled remotely in the presence of an unknown external force resulting from needle-tissue interaction or gravity. The ult...

This manuscript is concerned with stability analysis of linear sampled-data systems with non-uniform sampling patterns. The stability problem is tackled from a continuoustime point of view, via the so-called “input delay approach”. The system is viewed as feedback interconnection of a stable linear time-varying system and the “average delay-difference” operator, which is utilized to model the “...

OBJECTIVES To identify the main symptoms of retinoblastoma and to determine the mean time between symptom onset and diagnosis (lag time). PATIENTS AND METHODS We carried out a retrospective analysis of the patients diagnosed with retinoblastoma between January 1991 and June 2000, at the Pediatric Department of the Hospital do Cancer, Sao Paulo, Brazil. Statistical analyses performed were: Stu...

This dissertation covers the two major parts of my PhD research: i) Modeling instantaneous correlation ii) Quantifying time-lag correlation iii) Modeling time-lag correlation iv) Modeling and application of heteroskedasticity. For modeling instantaneous correlation, we studied the limitations of random matrix theory (RMT), and proposed autoregressive random matrix theory (ARRMT) which take into...

Besides parametric uncertainties and disturbances, the unmodeled dynamics and time delay at the input are often present in practical systems, which cannot be ignored in some cases. This paper aims to solve output feedback tracking control problem for a class of nonlinear uncertain systems subject to unmodeled high-frequency gains and time delay at the input. By the additive state decomposition,...

The duration of symptoms before diagnosis (lag time) was defined for 184 of 236 children diagnosed as having a malignancy at the Royal Hospital for Sick Children, Edinburgh for the time period January 1982 until December 1990. The natural logarithm of the lag time was correlated with age, gender, diagnostic group, white cell count in acute leukaemia, clinical stage of disease in solid tumours, ...