background: evidences suggest an association between the prevalence of thyroid peroxidase (anti-tpo) and anti thyroglobulin (anti-tg) with recurrent abortions and infertility. iodine deficiency was once endemic in iran and little data is available about the prevalence of these antibodies in different groups of fertile or infertile individuals. objective: this case control study was designed to ...

nomously functioning thyroid nodule 505 InTROduCTIOn Diagnostic procedures for thyroid disorder include bio chemical evaluation: measurement of serum thyrotropin (TSH), free thyroid hormone (free thyroxine [FT4], free triiodothyronine [FT3]) and thyroid antibody levels, as well as imaging including ultrasonography (USG) and thyroid scan. In some cases fine needle aspiration bio psy (FNAB) shoul...

UNLABELLED Our purpose was to determine the clinical significance of diffusely increased (18)F-FDG uptake in the thyroid gland as an incidental finding on PET/CT. METHODS All patients who were found to have diffuse thyroid uptake on (18)F-FDG PET/CT in our institution between November 2004 and June 2006 were investigated and compared with an age- and sex-matched control group. The (18)F-FDG u...

OBJECTIVE This study was designed to assess the efficiency of the serum thyrotropin to thyroglobulin ratio for thyroid nodule evaluation in euthyroid patients. STUDY DESIGN Cross-sectional study. SETTING Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China. SUBJECTS AND METHODS Retrospective analysis was performed for 400 previously untreated cases present...

OBJECTIVE The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC). SUBJECTS AND METHODS 12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), t...

AIMS/BACKGROUND Thyroid associated ophthalmopathy (TAO) of euthyroid patients is difficult to diagnose because clinical findings overlap with other conditions, and no confirmatory diagnostic tests are available. Recently, it was reported that TSH binding inhibitor immunoglobulin (TBII) and thyroid stimulating antibody (TSAb) are sensitive markers of TAO. The sensitivity of these antibodies in t...

The cloning and sequencing of thyroid-stimulating hormone (TSH) receptor (TSHR), combined with advances in molecular techniques, have facilitated the understanding of the interaction of the TSHR antibodies (TSHRAbs) with the TSHR at the molecular level and have allowed the delineation of their clinical role. TSHRAbs in vivo are functionally heterogeneous; the stimulating TSHRAbs cause hyperthyr...

Genetic factors are thought to be an important determinant of thyroid function and autoimmunity. However, there are limited data on genetic variants in Asians. In this study, we performed a genome-wide association study on plasma thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration and anti-thyroid peroxidase (anti-TPO) antibody positivity in 4238 Korean subjects. In the Sta...

Many hypothyroid and autoimmune thyroid patients experience reactions with specific foods. Additionally, food interactions may play a role in a subset of individuals who have difficulty finding a suitable thyroid hormone dosage. Our study was designed to investigate the potential role of dietary protein immune reactivity with thyroid hormones and thyroid axis target sites. We identified immune ...