The medicinal plant Olea europaea L. is a valuable one whose fruit and its oil are considered as food. There are some reports in ancient medical literature that aqueous extract of its leaves has analgesic effects. This prompted us to investigate the analgesic effect of aqueous extract of its leaves using formalin and tail-flick tests. For this purpose, male NMRI rats weighting 220-260 g were us...

introduction: methadone has been used as a drug to detoxify opioid tolerance. naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. on the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking...

The medicinal plant Olea europaea L. is a valuable one whose fruit and its oil are considered as food. There are some reports in ancient medical literature that aqueous extract of its leaves has analgesic effects. This prompted us to investigate the analgesic effect of aqueous extract of its leaves using formalin and tail-flick tests. For this purpose, male NMRI rats weighting 220-260 g were us...

Conium maculatum Linn. (Umbelliferae) has been traditionally used in the treatment of spasmodic disorders, and to relieve nervous excitation, rheumatic pains in the old and feeble, pain in stomach, pain of gastric ulcer, nervousness and restlessness. Alkaloids have long been considered as bioactive group of constituents present in C. maculatum. Despite a long tradition of use, C. maculatum has ...

* Corresponding Author: Abbas Haghparast, Msc, PhD Associate Professor of Neurophysiology, Single Unit Recording Laboratory, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Evin St., Shahid Chamran Exp.way. P.O.Box: 19615-1178, Tehran, IRAN Tel/Fax: +98 21 2243 1624. Mobile: +98 912 214 9857 E-mail: Dr. [email protected]. Website: http://www.nrciran.com/ Introdu...

Pain is a universal complaint, which needs further investigations for new pain relieving agents. Carum copticum (L.) Sprague ex Turrill is a plant in Umbelliferae family, which is mentioned to have some therapeutic effects on headache and joint pains in Iranian traditional literature, but there are not enough scientific reports to prove its effects on pain. So, we conducted to design an experim...

The l-isomer of methadone possesses opioid activity, whereas the d-isomer is weak or inactive as an opioid. Both d- and l-methadone have been shown to bind to the N-methyl-D-aspartate (NMDA) receptor. To determine whether d-methadone has functional, in vivo NMDA receptor antagonist activity, the antinociceptive effects of d-methadone were evaluated in the rat tail-flick and formalin tests. Cumu...

D-amino acid oxidase (DAO) is an enzyme catalyzing oxidative deamination of neutral and polar d-amino acids and is expressed in the kidneys, liver, and central nervous system (CNS) including the spinal cord. We have previously demonstrated that DAO gene deletion/mutation by using mutant ddY/DAO(-/-) mice and systemic administration of the DAO inhibitor sodium benzoate blocked formalin-induced h...

introduction: in order to study the alterations of beta 1 and 2 integrins mrna level in rat lumbar spinal cord following the induction of chronic pain and its effect on the development of tolerance to morphine analgesia, we examined the level of expression of these genes in the presence of chronic pain, which is an inhibitor of morphine tolerance. we used induction of chronic pain alone and in ...

   Our previous study showed that Coriandrum sativum (CS) has antinociceptive effects, but the mechanisms that mediate this effect are not clear. The present study was designed to test the role of opiate system in the antinociceptive effects of CS on acute and chronic pain in mice using Hot Plate (HP), Tail Flick (TF) and Formalin (FT) tests and also to compare its effect with dexamethasone (DE...