Within one year three of 25 patients with rheumatoid arthritis treated with azathioprine 100 mg daily developed the following adverse reactions less than two weeks after starting treatment: patient one showed fever with chills, rash, and severe liver function abnormalities suggestive of cholestasis; the second patient had fever, nausea, diarrhoea, and moderately raised liver enzymes; the third ...

BACKGROUND/AIMS Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipogenesis, was shown to be associated with non-alcoholic fatty liver disease, which is attributed to its major isoform SREBP1c. Based on studies in mice, the minor isoform SREBP1a is regarded as negligible for hepatic lipogenesis. This study aims to elucidate the expression and functional role of SREB...

Background: Hepato cellular carcinoma (HCC) represents a challenging malignancy of worldwide importance; it is the sixth most common cancer and the third most common cause of cancer-related death globally. Alcohol, tobacco, obesity, diabetes and viral etiology interact to increase the risk of HCC in patients with chronic liver diseases. Smoking is a well documented risk factor for many cancers ...

(a) 1 and 2: two successive extracts (30min each) from mouse liver chromatin; 3 and 4: the same from spleen chromatin; 5 and 6: the same from mouse kidney chromatin. Abbreviation used: LSP, liver specific protein. (b) 1-4: four successive 0.25 M-HCl extracts from mouse liver chromatin. Proteins were strained with Coomassie Brilliant Blue, and gel electrophoresis was performed by the method of L...

A young man presented with a large liver mass and positive hepatitis B virus markers. This 18-year-old male has developed ascites, jaundice, high serum alpha fetoprotein (AFP) level, liver mass and portal hypertension, without fever or calcification in the mass. All favored the diagnosis of rapidly, progressive hepatocellular carcinoma, however proven hepatoblastoma in liver biopsy. Hepatoblast...

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with ...

A 26-year old woman with history of congenital biliary atresia and Kasai procedure as a newborn presented with recurrent nausea and abdominal pain. Physical examination showed anicteric sclera and tender right upper quadrant. Elevated liver function tests suggested obstruction and hepatitis. Percutaneous transhepatic cholangiogram showed generalized ductal dilation, innumerable intrahepatic bil...

a vermiform specimen taken from a 10-year-old boy patient with the chief complain of sneezing, coughing and nasal dis-charge with a history of consumption of fast snack in the day before and liver of sheep in two weeks ago was referred for diagnosis to the helminth taxonomy laboratory, dept. of mdical parasitology and mycology, school of public health, tehran university of medical sciences, ira...

Liver transplantation is now the standard treatment for end-stage liver disease. Given the shortage of liver donors and the progressively higher number of patients waiting for transplantation, improvements in patient selection and optimization of timing for transplantation are needed. Several solutions have been suggested, including increasing the donor pool; a fair policy for allocation, not p...