نتایج جستجو برای: thiopurine methyltransferase

تعداد نتایج: 23287  

2004

Azathioprine has been available as an immunosuppressive agent for over 40 years, and current routine usage in dermatology is not restricted to licensed indications. Advances in understanding the metabolic fate of azathioprine have led to significant changes in prescribing practice and toxicity monitoring by U.K. dermatologists. The current state of knowledge concerning the use of azathioprine i...

Journal: :Journal of chromatography. B, Biomedical applications 1996
C W Keuzenkamp-Jansen P A Leegwater R A De Abreu M A Lambooy J P Bokkerink J M Trijbels

Thiopurine methyltransferase (TPMT) is an important enzyme in the metabolism of 6-mercaptopurine (6MP), which is used in the treatment of acute lymphoblastic leukemia (ALL). TPMT catalyzes the formation of methylthioinosine monophosphate (MetIMP), which is cytotoxic for cultured cell lines, and it plays a role in detoxification of 6MP. Population studies show a genetic polymorphism for TPMT wit...

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