A rapid semiquantitative method for the determination of anticonvulsant drugs in blood and urine by thin-layer chromatography is described that is applicable in most laboratories.Utilization of SilicAR TLC-7GF with benzene:acetone (4:1), chloroform:acetone(9:1), and carbontetrachloride:acetone(7:3) providesseparationof Dilantin,phenobarbital, Mysoline,Phenylethylmalondiamide, Mesantoin,and Nirv...

A systematic appraisal of a large number of solvent systems was carried out for the separation of lactic, pyruvic and 3-hydroxybutyric acids and all of the KREBS cycle acids, except oxalosuccinic, using silica gel G and cellulose thin layer Chromatographie plates. Four solvent systems which allowed separation of various combinations of acids are described and the limits of this method of separa...

Globalization forces analysts to demand extended control of variability in analytical measurements. A calculation procedure named the "error budget model" following recommendations proposed more than 20 years ago by the Bureau International des Poids et Mesures is established as a rule for evaluating and expressing the measurement uncertainty across a broad spectrum of measurements. This metrol...

NilEDICATIONS are one of the leading causes of fatal and nonfatal poisonings. Of all medications, salicylates (in children) and barbiturates (in adults) are most frequently involved in these poisonings. When these occur, the physician treating the victim may request a chemical analysis of a blood sample to confirm his clinical impression. A salicylate analysis is simple and rapid (1). However, ...