An optimized method for the synthesis of new 2-substituted-thiazolo[2,3-a]benzimidazole-3(2H)-ones was developed which enabled the target compounds to be obtained in relative good yields through one pot process.Four cancer cell lines: human colorectal cancer cell line HT-29, breast cancer cells MDA-MB-231, cervical cancer cells HeLa, human liver carcinoma cell line HepG2 and human diploid cell ...

Abstract The synthesis of alicyclic 2-methylenethiazolo[2,3-b]quinazo­l­inones is performed via base-promoted cascade reactions, starting from either β-amino propargylamides using carbon disulfide, or ethyl 2-isothiocyanatocarboxylates by addition propargylamine. In both cases the reaction proceeds way a favoured 5-exo-dig process during second ring closure, as confirmed full NMR spectroscopic ...