As one kind of “smart” material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. In this work, we report a thermosensitive poly(2-oxazoline)/poly(2-oxazine) based diblock copolymer comprising thermosensitive/moderately hydrophobic poly(2-N-propyl-2-oxazine) (pPrOzi) hydrophilic poly(2-ethyl-2-oxazoline) (pEtOx). Hydrogels were only formed whe...

Affinity-Modulation Drug Delivery Using Thermosensitive Elastin-Like Polypeptide Block Copolymers by Andrew J. Simnick Department of Biomedical Engineering Duke University Date:_______________________ Approved: ___________________________ Ashutosh Chilkoti, Ph.D., Supervisor ___________________________ Mark W. Dewhirst, Ph.D., D.V.M. ___________________________ Kam W. Leong, Ph.D. _____________...

Biodegradable thermogelling copolymer hydrogels have great applicative potential in areas such as sustained drug release, gene delivery and tissue engineering. These injectable materials can be implanted in the human body with minimal surgical intervention. The thermosensitive copolymers have been incorporated with a variety of biocompatible and biodegradable components such as poly(D,L-lactic ...

This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the University of California, San Francisco Medical School. He is a member of the National Academy of Sciences and has received many distinguished aw...

We discuss the nonlinear rheology of dense colloidal dispersions at the glass transition. A first principles approach starting with interacting Brownian particles in given arbitrary homogeneous (incompressible) flow neglecting hydrodynamic interactions is sketched. It e.g. explains steady state flow curves for finite shear rates measured in dense suspensions of thermosensitive core-shell partic...

ANTICANCER DRUGS BY USE OF THERMOSENSITIVE AMPHIPHILIC BLOCK COPOLYMER Kenji Kono, Toshiaki Ozawa, Chie Kojima, Atsushi Harada, Shokyoku Kanaoka, Sadahito Aoshima, Kazuo Maruyama, and Yukihito Ishizaka Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 5998531, Japan Department of Macromolecular Science, Graduate S...

Bacterial infection and poor cell recruitment are among the main factors that prolong wound healing. To address this, a strategy is required can prevent while promoting tissue repair. Here, we have created silver nanoparticle-based hydrogel composite antibacterial provides nutrients for growth, filling cavities of various geometries in wounds difficult to reach with other dressings. Silver nano...