Healthcare spending in Canada has grown rapidly in recent years, especially for drugs. This paper discusses the causes of the problem and makes policy proposals. Conflicts of interest (COIs) are a frequent occurrence in medical research and lead to bias. Published studies, especially in the area of clinical trials on drugs, are much more likely to produce findings favourable to the drug when fu...

This paper investigates an isolated setting of the lexical substitution task of replacing words with their synonyms. In particular, we examine this problem in the setting of subtitle generation and evaluate state of the art scoring methods that predict the validity of a given substitution. The paper evaluates two context independent models and two contextual models. The major findings suggest t...

conclusions the designed safe irrigator syringe seems to be applicable in wound irrigation and superior to the conventional devices regarding efficacy and user comfort. results all of the interns stated that the new device is quite applicable for wound washing and is easy to handle. nine interns believed that safe irrigator syringe is superior to the conventional devices regarding efficacy and ...

aim and background: the therapeutic community (tc) is a residential treatment model, which is effective in the treatment of people with substance abuse disorder. the aim of the people study was to examine the effectiveness of tc on mental symptoms of persons with substance abuse disorder. methods and materials: in this experimental, pre-post test and follow-up study, referred patients with subs...

background and objectives: typhoid is a major health problem faced by the developing countries like pakistan. more than 20 million cases are reported annually worldwide. currently fluoroquinolones are the drugs of choice to treat typhoid fever. in vivo resistance to fluoroquinolones leading to therapeutic failure is developing rapidly and is becoming a major concern for the clinicians. the obje...

introduction percutaneous nephrolithotomy (pcnl) is a standard, safe, and efficient method for removing large renal calculi. despite development of endourologic equipment, complications of the pcnl are still prevalent. even though therapeutic modalities such as mini-micro pcnl have been developed in recent years, the complications are a serious concern yet. the most important complication is he...

The Department of Defense (DoD) is publishing this final rule to remove the exclusion of drug maintenance programs and allow TRICARE coverage of the substitution of a therapeutic drug, with addictive potential, for a drug of addiction when medically necessary and appropriate as part of a comprehensive treatment plan for an individual with substance use dependence. The current regulation prohibi...

The surgical treatment of multi-recurrent large incisional hernias represents a problem of medical actuality which still requires studies and interpretations, meant to clarify the most correct therapeutic behavior to obtain the best results. Important progress has been made in this field by solving the principles of the surgical treatment based on more precise notions of anatomy and physiology ...

The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-001 virotherapy with a peptide prodrug activated by the viral protease 3Cpro is a novel strategy that may increase the therapeutic potential o...

BACKGROUND Upon admission to a hospital patients' medications are frequently switched to alternative drugs compiled in so called hospital drug formularies. This substitution process is a laborious and error-prone task which should be supported by sophisticated electronic tools. We developed a computerised decision support system and evaluated benefit and potential harm associated with its use. ...