spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...

concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. although these recommendations are not specific to children, the values can be extrapolated. this prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...

background: since the treatments of long tracheal leisions are associated with some limitations, tissue enginered trachea is considered as an alternative option. this study aimed at preparing a composite scaffold, based on natural and synthetic materials for tracheal tissue engineering. methods: nine chitosan silk-based scaffolds were fabricated using three freezing rates (0.5, 1, and 2°c/min) ...

colorectal cancer is one of the most prevalent cancers in the world. it's survival expectancy depends on the time of diagnosis, stage and grade of the tumor, and general condition of the patient. survival expectancy of this type of cancer reveals the quality of diagnostic and therapeutic services in the community. to improve and standardize the treatment modalities in this field, much rese...

Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a patient's response to commonly prescribed drug classes, including beta blockers and antidepressant...

The use of ?-lactamase inhibitors in combination with ?-lactam antibiotics is an emerging area drug discovery. This strategy allows the restoration therapeutic efficacy these clinical against multiresistant bacteria. These pathogens are resistant because they express enzymes, which prevent antibiotic action by catalyzing hydrolysis ring. enzymes quite diverse both their structural architecture ...

conclusions the determination of warfarin dose, based on genotyping, might reduce the time to achieve stable anticoagulation of warfarin dose and length of hospital stay. patients and methods in this prospective cohort study, 200 pediatric patients, who required warfarin therapy after cardiac surgery, were enrolled and divided into two groups. for 50 cases, warfarin was prescribed based on thei...

The recently discovered enzymes that process the precursors of inflammatory cytokines are good targets for the design of new anti-inflammatory therapeutic agents.

Abstract The current work examined the therapeutic potential of 6-aminoflavone (6AF) against mouse model-based oxidative stress-driven synaptic and memory impairment caused by lipopolysaccharides (LPSs). In brains experimental mice, LPS administration for 3 weeks significantly increased stress inhibiting antioxidant enzymes, including superoxide dismutase, peroxidase, catalase, glutathione, upr...

Abstract The treatment of neuropsychiatric and neurodegenerative disorders such as depression Parkinson’s disease represent significant challenges in healthcare. Enzymes that metabolise neurotransmitter amines are important drug targets for these inhibitors enzymes have played key roles therapeutic agents. For example, monoamine oxidase (MAO) A been used decades antidepressant agents act by inh...