BACKGROUND Elevation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) is prominent in acute dengue illness. The World Health Organization (WHO) 2009 dengue guidelines defined AST or ALT ≥ 1000 units/liter (U/L) as a criterion for severe dengue. We aimed to assess the clinical relevance and discriminatory value of AST or ALT for dengue hemorrhagic fever (DHF) and severe den...

BACKGROUND Hepatocellular carcinoma (HCC) is a major health problem worldwide with increasing incidence rates. As HCC traditionally occurs in chronically inflamed livers, this inflammation aids to drive oncogenesis and often renders these lesions to be immunogenic and therefore potential targets for immunotherapy. As patients with HCC generally have underlying liver dysfunction, we sought to de...

We studied the effects of black fat-tailed scorpion (Androctonus bicolor) venom on the activities of liver enzymes including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH) and creatine kinase (CK) in the sera of rats. The animals were subcutaneously injected with a single dose of crude A...

Increased serum concentrations of several intracellular enzymes have been reported to be useful in establishing the diagnosis and prognosis of hepatopathies in the horse. These include alanine aminotransferase (ALT), alkaline phosphatase (AP), arginase, aspartate aminotransferase (AST), gamma glutamyltranferase (γGT), glutamate dehydrogenase (GLDH), iditol dehydrogenase (IDH) and lactate dehydr...

AIMS To assess the place of AST/ALT ratio (the ratio of serum aspartate aminotransferase to serum alanine aminotransferase) as a diagnostic marker in medical populations. METHODS Laboratory tests were viewed retrospectively in three groups of patients: 313 patients with alcohol dependence, consecutively admitted to an alcohol and drug treatment unit for treatment of withdrawal (W) symptoms, 7...

Fenvalerate is a synthetic pyrethroid , widely used due to its high effective and low mammalian toxicity. Fenvalerate, dose equivalent to LD25 was administered orally for acute exposure and dose equivalent to LD5 for subchronic & chronic exposure to Wistar rats. Toxic effect of Fenvalerate observed in serum Lypase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), Cholinesterase...