I want to begin by thanking the PNG Government, the University of Papua New Guinea and the Development Policy Centre of the ANU for the opportunity to revisit PNG and participate in this important conference. Having a regular country-driven discussion of key development issues is clearly a best practice and needs to be supported as a key input into policy decision making. I am particularly impr...

The publication of the first article in this issue, “Realizing Strategic Value through Center-Edge Digital Transformation in Consumer-Centric Industries,” provides a unique opportunity to pay tribute to the first author, Paul Gray, who passed away last year. Please join me in thanking Omar El Sawy, Guillermo Asper, and Magnus Thordarson for continuing to revise this article co-authored with Pau...

iii ACKNOWLEDGEMENTS I would like to start by thanking my advisor, Dr. Zhong Lin Wang, for his support and guidance during my time here at Georgia Tech. I will never forget the trust and academic freedom he gave me to pursue a research topic that would not only be challenging, but may have proven fruitless, as it has for so many other researchers in the past. It is thanks to him that I was able...

i ABSTRACT As we migrate into an era of personalized medicine, understanding how bio-molecules interact with one another to form cellular systems is one of the key focus areas of systems biology. Several challenges such as the dynamic nature of cellular systems, uncertainty due to environmental influences, and the heterogeneity between individual patients render this a difficult task. In the la...