s | 11 and path of small molecule. FITC-dextran (4kDa) was injected into cortices of young, aged, and AD mice. Centering the injection site, circle mask was divided into eight pieces, which were classified into artery or vein-dominant based on vessel distribution. We compare the intensity and decline rates of FITC signal at each piece of the mask. The discrepancy transforms into the uniformity ...

S of the 61 Annual Meeting of the Society of Thrombosis and Hemostasis Research 15-18 February 2017 Basel, Switzerland Differential effects of novel anticoagulants: FXa versus FIIa inhibition on coagulation and inflammation S. Nazir, K. Shahzad, I. Gadi, M. Al-Dabet, S. Kohli, S. Ranjan, F. Bock, B. Isermann (Magdeburg, Germany, Nashville, United States) Basic Science 16.02.2017, 11:00 12:00 Ob...

The cornified envelope is a layer of transglutaminase cross-linked protein that is deposited under the plasma membrane of keratinocytes in the outermost layers of the epidermis. We present the sequence of one of the cornified envelope precursors, a protein with an apparent molecular mass of 210 kD. The 210-kD protein is translated from a 6.5-kb mRNA that is transcribed from a single copy gene. ...

ion of an InH-Prolog proof. Lost is the localness property of LJ but gained is a more directed backchaining search, where the _-LEFT rule need not be used blindly. It is instructive to note how small a change to the intuitionistic calculus LJ is needed to yield this complete proof procedure for rst-order (classical) logic. (One should note that the conversion of an arbitrary rst-order formula t...

Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the length of the desired capped RNA, chemical or enzymatic preparation – or a combination of both – can be advantageous. We review state-of-the art methods and give directions for choosing the appropriate approach. We a...