Transforming growth factor (TGF)-β superfamily proteins have many important biological functions, including regulation of tissue differentiation, cell proliferation, and migration in both normal and cancer cells. Many studies have reported that TGF-β signaling is associated with disease progression and therapeutic resistance in several cancers. Similarly, TGF-β-induced protein (TGFBI)-a downstr...

There are multiple mechanisms by which cells evade TGF-b–mediated growth inhibitory effects. In this report, we describe a novel mechanism by which cells become resistant to TGF-b–mediated growth suppression. Although having all the components of the TGF-b signaling pathway, different cell lines, RL, HaCaT, and BJAB, have different sensitivities toward TGF-b–induced growth suppression. The TGF-...

Background and Purpose—Unstable atherosclerotic plaques are characterized by increased macrophages and reduced smooth muscle cells (SMCs) and collagen content. Endoglin, an accessory transforming growth factor(TGF ) receptor, is a modulator of TGF signaling recently found to be expressed on SMCs in atherosclerotic plaques. Its function in plaque SMCs and plaque development is unknown. Early gro...

BACKGROUND Transforming growth factor type-β (TGF-β)/Smad pathway plays an essential role in vascular fibrosis. Reactive oxygen species (ROS) generation also mediates TGF-β signaling-induced vascular fibrosis, suggesting that some sort of interaction exists between Smad and redox pathways. However, the underlying molecular mechanism is largely unknown. This study aims to investigate the influen...

Transforming growth factor beta (TGF-beta) regulates a variety of physiologic processes, including growth inhibition, differentiation, and induction of apoptosis. Some TGF-beta-initiated signals are conveyed through Smad3; TGF-beta binding to its receptors induces phosphorylation of Smad3, which then migrates to the nucleus where it functions as a transcription factor. We describe here the asso...

There are multiple mechanisms by which cells evade TGF-β-mediated growth inhibitory effects. In this report, we describe a novel mechanism by which cells become resistant to TGF-β-mediated growth suppression. Although having all the components of the TGF-β signaling pathway, different cell lines, RL, HaCaT, and BJAB, have different sensitivities toward TGF-β-induced growth suppression. The TGF-...

Cutaneous lupus erythematosus (CLE) is a manifestation of systemic (SLE) that can cause significant patient distress due to scarring. Mechanisms scarring remain poorly understood and interventions for prevention treatment are lacking. Fibroblasts (FBs) involved in inflammation scarring, yet the role inflammatory mediators on FB function SLE unclear. In this study, we examined phenotype FBs isol...

There are multiple mechanisms by which cells evade TGF-b–mediated growth inhibitory effects. In this report, we describe a novel mechanism by which cells become resistant to TGF-b–mediated growth suppression. Although having all the components of the TGF-b signaling pathway, different cell lines, RL, HaCaT, and BJAB, have different sensitivities toward TGF-b–induced growth suppression. The TGF-...

Abstract Background Intramuscular fat (IMF) content is a vital parameter for assessing pork quality. Increasing evidence has shown that microRNAs (miRNAs) play an important role in regulating porcine IMF deposition. Here, novel miRNA implicated adipogenesis was found, and its effect regulatory mechanism were further explored with respect to intramuscular preadipocyte proliferation differentiati...

The present study aimed to determine the underlying molecular mechanism of the antifibrotic effect of artesunate in pulmonary fibrosis (PF). Primary lung fibroblasts were isolated from the lung tissues of rats, and treated with artesunate (8 µg/ml) and transforming growth factor (TGF)-β1 (5 ng/ml). For in vivo experiments, the rats were administered bleomycin intratracheally, followed by daily ...