Determining the optimal timing for histopathological examination following exposure to a test article is crucial assessing neurotoxicity. However, no study has focused on identifying an ideal dataset define of central nervous system (CNS) toxicity in monkeys. Therefore, this aimed predictive endpoint that would guide us selecting CNS Four cynomolgus monkeys were administered 1-methyl-4-phenyl-1...

Purpose: To study the potential neuroprotective effects of tanshinone IIA, a diterpene quinone, in an experimental model 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
 Methods: Mice (C57BL/6) were administered freshly-prepared MPTP at dose 20 mg/kg body weight intraperitoneally, 4 times 2-h intervals, to induce PD. Doses 12.5, 25 and 50 IIA mice as ...

An efficient synthetic strategy was developed to modulate the structure of the tetrahydropyridine isoindolone (Valmerin) skeleton. A library of more than 30 novel final structures was generated. Biological activities on CDK5 and GSK3 as well as cellular effects on cancer cell lines were measured for each novel compound. Additionally docking studies were performed to support medicinal chemistry ...

As part of our search for anti-breast cancer agents a new series of tricyclic 4-substituted-2-yl)-2thioxo-3, 4-dihydro-1H-indeno [1, 2-d] pyrimidin-5(2H)-one 4-9 were obtained in one pot synthesis by a modification of the Biginelli Reaction. The structures of the synthesized compounds were characterized by microanalyses, IR, H-NMR, C-NMR and mass spectral data. All the synthesized compounds wer...