نتایج جستجو برای: testis tissue damage
تعداد نتایج: 1116623 فیلتر نتایج به سال:
Present study examined the impact of copper (Cu) as nanoparticle (Cu-NPs) and soluble form (CuSO4) in adult male catfish Clarias batrachus. Following treatment, upregulation of transcripts of several testis-related genes and increased androgen levels were evident. Though profound promotional effect was seen at gene and androgen levels, structural analysis revealed completely different scenario....
Cisplatin is an effective chemotherapeutic drug used to treat many types of tumours. However, it may cause male reproductive toxicity. Gallic acid exhibits beneficial effects such as antioxidant, anti-inflammatory and antitumor. The current study investigated the gallic against testis epididymis toxicity induced by cisplatin. Male rats were divided into 4 groups follows (n = 7): Control, cispla...
The multidrug resistance protein 1 (MRP1) gene encodes a transporter protein that helps to protect cells against xenobiotics. Elevated levels of MRP1 in tumor cells can result in active extrusion of a wide range of (anticancer) drugs with different cellular targets, a phenomenon called multidrug resistance (MDR). To explore the protective function of the mouse mrp1 protein during drug treatment...
Background: Fluoxetine, a selective serotonin reuptake inhibitor, has been prescribed for the treatment of depression and has shown also efficacy in the treatment of bulimia nervosa and obsessive-compulsive disorder. Grape seed extract is a natural extract from the seeds of graps. It contains the most beneficial groups of plant flavonoids, proanthocyanidins oligomers. These flavonoids are poten...
Ganoderma lucidum (GL) is a widely used medicinal mushroom. The therapeutic effect of this fungus on many diseases has been proven by studies. aim study to assess the effects low, moderate and high dose GL extract administration testis tissue, spermatogenic series cells sperm motility in rats. 40 Wistar albino rats were randomly divided into 4 groups. Rats group 1, 2, 3 administered 2 ml physio...
Controversies and debates still prevail in current literature concerning the role of bacterial infection male infertility. A handful studies have discovered a correlation between bacteria azoospermia condition which discharge is utterly devoid spermatozoa. In line with this, present study was designed to evaluate influence Escherichia coli on spermatogenesis. single dose (108 cfu/20ul) uropatho...
immediate response of eukaryotic cells to oxidative. PARP-1 and PARP-2 display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. Recent studies suggest a link between DNA damage-induced poly(ADP-ribosyl)ation and all tissues at varying levels, with the highest activity in mammalian testis, spleen and thymus. in particula...
Cancer-testis (CT) Ags are attractive targets for immunotherapeutic strategies since they are aberrantly expressed in malignant cells and not, or in limited number, in somatic tissues, except germ cells. To identify novel CT genes in multiple myeloma, we used Affymetrix HG-U133 gene expression profiles of 5 testis, 64 primary multiple myeloma cells (MMC), and 24 normal tissue samples. A 5-filte...
Corticosterone is synthesized in the adrenal glands and is circulated throughout the body to perform regulatory functions in various tissues. The testis is known to synthesize and secrete testosterone and other androgens. We developed an accurate method to measure steroid content using liquid chromatography-mass spectrometry analysis. In the present study, significant levels of the precursor co...
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