objective(s):  the field of nanotechnology is rapidly expanding .the development quantum dots quantum dot (qds), show great promise for treatment and diagnosis of cancer and targeted drug delivery little data on the toxicity of qds, especially for in vivo applications, are available. as a result, concerns exist over their toxicity for in vivo applications. then, cytotoxic effects of cadmium sel...

Objective: The aim of this study was to investigate the protective effect CAPE on oxidative stress and apoptosis against streptozotocin (STZ)-induced damage in rat testis after diabetes. Materials methods: rats were randomly divided into 4 groups: Control animals, animals given CAPE, STZ-induced diabetic CAPE. Diabetes induced by a single intraperitoneal injection STZ (55 mg/kg). Testicular exa...

Leydig cells are thought to be the source of most, if not all, the testosterone produced by the testis. The goal of this study was to obtain quantitative information about rat Leydig cells and their organelles that might be correlated with pertinent physiological and biochemical data available either now or in the future. Morphometric analysis of Leydig cells in mature normal rats was carried o...

Background & Aims: Sodium arsenite, an environmental pollutant, produces free radicals with harmful effects on the reproductive system. The aim of this study was to investigate the effect of curcumin, as a strong antioxidant, on the testis tissue and spermatogenic cell population in mice treated with sodium arsenite. Methods: In this experimental study, A...

Objective(s) In recent years concerns have been raised regarding the incidence of male reproductive disorders from exposure to endocrine disruptors. So, chronic effects of di(2-ethylhexyl)phthalate were studied on histological and stereological structure of testis in adult Wistar rats. Materials and Methods Thirty two adult Wistar rats were randomly divided in four equal experiment groups; o...

Mammalian spermatogenesis occurs in a precise and coordinated manner in the seminiferous tubules. One of the attempts to understand the detailed biological process during mammalian spermatogenesis at the molecular level has been to identify the testis specific genes followed by study of the testicular expression pattern of the genes. From the subtracted cDNA library of rat testis prepared using...

Spermatogenesis is a highly coordinated physiological process that requires the correct expression and functions of thousands of developmentally regulated genes. The regulation of spermatogenesis is not well defined, since majority of the related genes have neither been identified nor fully characterized. Hence, it is meaningful to identify and characterize these genes to reveal the mechanism u...