In an attempt to isolate multipotent stem cells from foreskin in a long-term culture, we encountered an interesting phenomenon which was the conversion of the fibroblast dominant condition to epithelial-like tissue formation. However, the basic mechanism(s) which may be involved in this conversion is not clear. This study was designed to evaluate the cells protein secretion activity and examine...

OBJECTIVE To study whether acute lymphoblastic leukemia (ALL) cells survive in a human testicular cell culture system. DESIGN Experimental laboratory study. SETTING Reproductive biology laboratory, academic medical center. PATIENT(S) Acute lymphoblastic leukemia cells from three patients and testicular cells from three other patients. INTERVENTION(S) Acute lymphoblastic leukemia cells w...

the adrenal gland of notopterus notopterus (pallas) consisted of interrenal and chromaffin cells, distributed around the main branches of posterior cardinal vein in most anterior part of the pronephric kidney. seasonal histological characteristics of the interrenal and chromaffin cells in relation to testicular activity of n. notopterus were studied by adopting different staining techniques. th...

Epithelial-myoepithelial carcinoma (EMC) is considered as a rare malignant salivary gland neoplasm with good prognosis, low recurrence rate and rare metastasis. Here we present a case of epithelial-myoepithelial carcinoma in a 42-year-old female with a swelling of 3-year duration in her palate. Histopathologic evaluation of the lesion demonstrated a well-circumscribed, biphasic salivary gland t...

Hormone-sensitive lipase (HSL, Lipe, E.C.3.1.1.3) is a multifunctional fatty acyl esterase that is essential for male fertility and spermatogenesis and that also plays important roles in the function of adipocytes, pancreatic beta-cells, and adrenal cortical cells. Gene-targeted HSL-deficient (HSL-/-) male mice are infertile, have a 2-fold reduction in testicular mass, a 2-fold elevation of the...

testicular cancer is one of the commonest cancers in men of working age, and is increasing in incidence in europe and north america. one suggested mechanism of causation is that there is impaired differentiation of germ cells in the pre- or perinatal period, followed by malignant transformation in later life, possibly by a hormonal mechanism. endocrine disrupting chemicals (edcs) have been a ma...

Objective- The purpose of this study was to evaluate the protective impacts of Plantago. major (P. major) against the adverse effects resulted from testicular ischemia/reperfusion (I/R) on kidney and liver.Design- Experimental study.Animals- Twenty-four male rats.Procedures- The testicular I/R was induced by f...

This review will focus the roles of TNF-alpha, IL-1 alpha, and IL-1 beta in the mammalian testis and in two testicular pathologies, testicular torsion and orchitis. TNF alpha in the testis is produced by round spermatids, pachytene spermatocytes, and testicular macrophages. The type 1 TNF receptor has been found on Sertoli and Leydig cells and numerous studies suggest a paracrine mode of action...

In this study, we examined the cellular origin and the expression levels of interleukin-6 (IL-6) during normal maturation of mouse testis. The levels of IL-6 (protein and mRNA) were higher in testicular homogenates of sexually immature than mature mice. Immunohistochemical staining of testicular tissues of sexually immature and adult mice show that testicular germ cells, at different stages of ...