Single structural defects involving the totality of ejaculated sperm are among rare cases of untreatable human male infertility. This form of infertility is of genetic origin and is generally transmitted as an autosomal recessive traits. Acrosome agenesis or globozoospermia results from perturbed expression of nuclear proteins or from an altered Golgi-nuclear recognition during spermiogenesis. ...

BACKGROUND Fertilization, cell division and embryo development depend on genomic contributions from male and female gametes. We hypothesize that teratozoospermic sperm influences early embryo development and embryo compaction. METHODS We conducted a retrospective analysis of embryos derived from intracytoplasmic sperm injection (ICSI) cycles. Two hundred thirty-five consecutive ICSI cycles we...

OBJECTIVE To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. DESIGN Placebo-controlled double-blind randomized trial. SETTING University tertiary referral center. PATIENT(S) Sixty infertile patients (aged 20-40 years) with the following baseline sperm selection criteria: concentration, 10 to 40 x 10(6)/m...

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2016;5(S1) tau.amegroups.com this study. Their obesity-associated markers were measured, and semen parameters were analyzed. Also, seminal plasma and serum TC, TG, HDL and LDL and serum FFA levels were detected. Results: Seminal plasma and serum TG, TC and LDL levels were positively related to age. Serum TC, TG and ...

A large body of evidence supports the protective role flavonol antioxidant compound quercetin in mammals. We tested hypothesis that can protect against hypothalamus-pituitary-gonadal (HPG) axis defect like a reduction gonadotropins and testicular hormones abnormal semen analysis induced by chronic unpredictable stress (CUS), possibly via downregulation oxidative (ROS) p53-Bax-caspase-3 pathways...