Exposure to various medications and medical conditions during pregnancy is often inevitable. Most of these exposures do not carry an elevated risk of congenital malformations. Nevertheless, misperceptions of the risks associated with different exposures in pregnancy are common and may potentially lead to wrong decisions. Unrealistically high maternal teratogenic risk perception may lead to abru...

The present article is an attempt to use the "ILSI Research Foundation/Risk Science Institute Reports from the Expert Working Group on Neurodevelopmental Endpoints" (2008) to help improve the quality of the manuscripts submitted to Neurotoxicology and Teratology, as well as the quality of their review. The points discussed in the present paper have been encountered during the peer-review proces...

Phenytoin has been the preferred drug for treating grand mal epilepsy for more than 40 years. The metabolism of this drug, its teratogenic potential, and its role in the pathogenesis of gingival overgrowth are discussed.

Embryos of the mummichog (Fundulus heteroclrtus) were exposed to 2, 5 , or 10 pg/L methylmercury (meHg) throughout development; these are concentrations below those which cause teratological effects in this species. After hatching, larvae were maintained in clean seawater and tested for prey-capture ability, using Artemia salina nauplii. Larvae that had been exposed to 10 pg/L methylmercury (an...

BACKGROUND Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries. OBJECTIVES To evaluate the efficacy and safety of a simple bi-daily treatment regimen with the combination of pyridoxine (50 mg twice daily) and doxylamine (25-50 mg) as an alternative treatment for NVP. ...

The use of fish embryos is gaining popularity for research in the area of toxicology and teratology. Particularly embryos of the zebrafish offer an array of different applications ranging from regulatory testing to mechanistic research. For this reason a consortium of two research centres and a company with the support of the COST Action EuFishBiomed has organised the Workshop “The zebrafish em...

Background and purpose: Teratological cases in insects can be of different characteristic, quite often they are bifurcations, for example antennal segments or parts the legs. The aim this paper is to report a remarkable case leg duplication Carabus violaceus L. Materials methods: In context an interdisciplinary monitoring frame conservation project on European bison (Bison bonasus (L.)) Poland ...

The number of chemicals in commerce which have not been evaluated for potential developmental toxicity is large. Because of the time and expense required by conventional developmental toxicity tests, an abbreviated assay is needed that will preliminarily evaluate otherwise untested chemicals to help prioritize them for conventional testing. A proposed short-term in vivo assay has been used in a...