One of the important sectors in low-income nations like Ethiopia is agriculture. To provide for needs its population terms food foundation an economy. It essential to nation's economy and gives people nation sources work. Many on African continent rely agricultural industry. Agriculture employs 85% labor force, accounts 50% GDP, 90% total exports, supplies 70% country's raw materials agro-indus...

Regulatory T cells (Treg) play a role in suppression of anti-melanoma immunity; however, the exact mechanism is poorly understood. Through intravital two photon microscopy, we found that Pmel-1 effectors engage in cell-cell interactions with tumor resident Tregs. To determine if contact between Tregs and T effectors (Teff) hinders killing of tumor cells in vivo, we utilized ex-vivo three-dimens...

OBJECTIVE All-trans retinoic acid (ATRA), a potent derivative of vitamin A, can regulate immune responses. However, its role in inducing immune tolerance associated with the prevention of islet inflammation and inhibition of type 1 diabetes remains unclear. RESEARCH DESIGN AND METHODS We investigated the mechanisms underlying the potential immunoregulatory effect of ATRA on type 1 diabetes us...

Regulatory T-cell (Treg, CD4(+) CD25(+)) dysfunction is suspected to play a key role in immune senescence and contributes to increased susceptibility to diseases with age by suppressing T-cell responses. FoxP3 is a master regulator of Treg function, and its expression is under control of several epigenetically labile promoters and enhancers. Demethylation of CpG sites within these regions is as...

We present an investigation of velocity fields in early to late M-type hydrodynamic stellar atmosphere models. These velocities will be expressed in classical terms of microand macroturbulent velocities for usage in 1D spectral synthesis. The M-star model parameters range between logg of 3.0 – 5.0 and Teff of 2500 K – 4000 K. We characterize the Teffand logg-dependence of the hydrodynamical vel...

Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression has long been the only therapeutic option, activating/expanding Tregs may achieve the same objective without the toxicity of immunosuppression. We showed that low-dose interleukin-2 (ld-IL-2) safely expands/activates ...

Context. The plateau in the abundance of 7Li in metal-poor stars was initially interpreted as an observational indicator of the primordial lithium abundance. However, this observational value is in disagreement with that deduced from calculations of Big Bang nucleosynthesis (BBN), when using the Wilkinson microwave anisotropy probe (WMAP) baryon density measurements. One of the most important f...

ABSTRACT We present UV photometry of the globular cluster NGC 1261 using images acquired with Ultraviolet Imaging Telescope (UVIT) on board Astrosat. performed point-spread function (PSF) four near-UV (NUV) and two far-UV (FUV) constructed colour–magnitude diagrams (CMDs), in combination Hubble Space (HST), Gaia, ground-based optical for member stars. detected full horizontal branch (HB) NUV bl...

ABSTRACT We explored here the near-infrared H-band atmospheric window aiming to provide quantitative diagnostic tools for deriving stellar parameters, instance, effective temperature (Teff) and metallicity ([Fe/H]), of cool giants (Teff < 5000 K) using low-resolution spectra. obtained 177 from X-shooter spectral library covering a wider range (−2.35 dex [Fe/H] 0.5 dex) than in earlier wo...